926927-55-1

Basic information

• Product Name: 2-Propenoic acid, 3-(4-bromo-2-nitrophenyl)-2-(cyanomethyl)-, ethyl ester, (2E)-
• CAS NO: 926927-55-1
• Molecular Formula: C13H11BrN2O4
• Molecular Weight: 339.145
• Mol File: 926927-55-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-(4-bromo-2-nitrophenyl)-2-(cyanomethyl)-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-(4-bromo-2-nitrophenyl)-2-(cyanomethyl)-, ethyl ester, (2E)-(926927-55-1)
• EPA Substance Registry System: 2-Propenoic acid, 3-(4-bromo-2-nitrophenyl)-2-(cyanomethyl)-, ethyl ester, (2E)-(926927-55-1)

Safety Data

• Hazardous Substances Data: 926927-55-1(Hazardous Substances Data)

Upstream product

• 135308-80-4 4-bromo-2-nitrobenzylidene diethanoate 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 5551-12-2 4-bromo-2-nitrobenzaldehyde 
• 174362-09-5 ethyl 3-cyano-2-(triphenylphosphoranylidene)propanoate 

Downstream Products

• 1268163-65-0 (1E,4E)-ethyl 2-(tert-butoxycarbonylamino)-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate 
• 1268163-73-0 tert-butyl (1E,4E)-4-(dipropylcarbamoyl)-8-(4-hydroxyphenyl)-3H-benzo[b]azepin-2-ylcarbamate 
• 1268163-30-9 (1E,4E)-2-amino-8-(4-hydroxyphenyl)-N,N-dipropyl-3H-benzo[b]azepine-4-carboxamide 
• 1268163-34-3 methyl 4-((1E,4E)-2-amino-4-(dipropylcarbamoyl)-3H-benzo[b]azepin-8-yl)benzoate 
• 1268163-53-6 tert-butyl (1E,4E)-8-(4-(dimethylcarbamoyl)phenyl)-4-(dipropylcarbamoyl)-3H-benzo[b]azepin-2-ylcarbamate 
• 1384958-42-2 (E)-ethyl 9-(4-(pyrrolidine-1-carbonyl)phenyl)-2,4-dihydro-1H-benzo[f]imidazo[1,2-a]azepine-5-carboxylate 

Relevant articles and documents

SULFINYLPHENYL OR SULFONIMIDOYLPHENYL BENZAZEPINES

This invention relates to novel sulfinylphenyl or sulfonimidoylphenyl benzazepine compounds of the formula (I) wherein X and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.

SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES

The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.