1353101-38-8

Basic information

• Product Name: 4-PyriMidinecarboxylic acid, 6-(trifluoroMethyl)-, Methyl ester
• Synonyms: 4-PyriMidinecarboxylic acid, 6-(trifluoroMethyl)-, Methyl ester;Methyl 6-(trifluoromethyl)-4-pyrimidinecarboxylate
• CAS NO: 1353101-38-8
• Molecular Formula: C7H5F3N2O2
• Molecular Weight: 206.1220096
• Mol File: 1353101-38-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-PyriMidinecarboxylic acid, 6-(trifluoroMethyl)-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PyriMidinecarboxylic acid, 6-(trifluoroMethyl)-, Methyl ester(1353101-38-8)
• EPA Substance Registry System: 4-PyriMidinecarboxylic acid, 6-(trifluoroMethyl)-, Methyl ester(1353101-38-8)

Safety Data

• Hazardous Substances Data: 1353101-38-8(Hazardous Substances Data)

Usage

Uses

Methyl 6-(trifluoromethyl)pyrimidine-4-carboxylate is a useful reagent in the preparation of tetrahydronaphthyridine derivatives as mGluR2-negative allosteric modulators.

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 37552-81-1 4-chloro-6-(trifluoromethyl)pyrimidine 

Relevant articles and documents

Spiro derivative, preparation method thereof and application of spiro derivative in medicine

The invention relates to a spiro derivative, a preparation method thereof and application of the spiro derivative in medicine. Specifically, the invention relates to the spiro derivative shown in a general formula (I), the preparation method thereof, a pharmaceutical composition containing the spiro derivative and application of the spiro derivative as a therapeutic agent, especially application of the spiro derivative as an RAF inhibitor and application of the spiro derivative in preparation of drugs for treating or preventing various diseases (including cancers) related to over-expression RAF activity.