135319-73-2

Basic information

• Product Name: (2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole
• Synonyms: (2rs,3sr)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1h-1,2,4-triazole;EPOXICONAZOLE;EPOCICONAZOLE;Epoxiconazole-2
• CAS NO: 135319-73-2
• Molecular Formula: C₁₇H₁₃ClFN₃O
• Molecular Weight: 329.76
• EINECS: 603-915-9
• Mol File: 135319-73-2.mol

Chemical Properties

• Boiling Point: 463.1 °C at 760 mmHg
• Flash Point: 233.9 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.659
• PKA: 2.75±0.10(Predicted)
• CAS DataBase Reference: (2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: (2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole(135319-73-2)
• EPA Substance Registry System: (2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole(135319-73-2)

Safety Data

• Hazard Codes: Xn:Harmful;;
• Statements: R40:; R51/53:; R62:; R63:
• Safety Statements: S36/37:; S46:; S61:
• Hazardous Substances Data: 135319-73-2(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
Epoxiconazole is used as a fungicide for the protection of various crops. It is effective against a broad spectrum of fungal diseases, such as powdery mildew, rust, and leaf spot, which can cause significant yield losses and affect the quality of the produce. By targeting the ergosterol synthesis in fungi, Epoxiconazole helps to prevent the growth and spread of these diseases, ensuring healthier crops and improved agricultural productivity.
Used in Plant Protection:
In addition to its application in agriculture, Epoxiconazole is also used in plant protection to safeguard ornamental plants and turf grasses from fungal infections. Its systemic action allows it to be absorbed by the plant and distributed throughout the tissues, providing long-lasting protection against a range of fungal pathogens. This helps to maintain the aesthetic appeal and health of landscapes, gardens, and sports fields.

InChI:InChI=1/C17H13ClFN3O/c18-15-4-2-1-3-14(15)16-17(23-16,9-22-11-20-10-21-22)12-5-7-13(19)8-6-12/h1-8,10-11,16H,9H2/t16-,17-/m0/s1

Upstream product

• 288-88-0 1,2,4-Triazole 
• 150344-44-8 2-chlorobenzyl 4-fluorophenyl ketone 
• 95-50-1 1,2-dichloro-benzene 
• 615-41-8 2-iodochlorobenzene 
• 350-40-3 2-(4-fluorophenyl)-1-propene 

Relevant articles and documents

Method for reducing 1,3,4-triazole substituent in 1,2,4-triazole alkylation reaction process

The invention relates to a method for reducing a 1,3,4-triazole substituent in 1,2,4-triazole alkylation reaction process. The method comprises the steps that 1, 2, 4-triazole and an alkylation reagent are subjected to an alkylation reaction in the presence of an alkali and a catalyst, after the reaction is finished, 1, 2, 4-triazole substituent is obtained through aftertreatment, and the catalystis one or a combination of more of polyether, cyclic crown ether, quaternary ammonium salt, quaternary phosphorus salt, quaternary ammonium base and tertiary amine. The method is simple to operate; the method is wide in application range, the content of the 1, 3, 4-triazole substituent in the alkylation reaction process can be reduced, the yield of the 1, 2, 4-triazole substituent is increased, the reaction time is shortened, the reaction temperature is reduced, solvent use is reduced or avoided, the resource utilization rate is increased, three wastes are reduced, the production cost is reduced, and the method meets the requirements of a green and environment-friendly process.

Epoxiconazole intermediate, preparation method thereof, and preparation method of epoxiconazole

The invention relates to an epoxiconazole intermediate, a preparation method thereof, and a preparation method of epoxiconazole. The epoxiconazole intermediate is a compound with a structural formulaIII shown in the description, and X in the formula III is Br or Cr. The preparation methods have the advantages of cheap and easily available raw materials, simple steps, high safety, few pollution ofthree wastes, mild reaction conditions, green, clean and environmentally-friendly reagents and reaction processes, suitableness for industrial production, and realization of high yield and high content of the final products.

Preparation method of epoxiconazole intermediate and epoxiconazole

The invention relates to a preparation method of an epoxiconazole intermediate and epoxiconazole. The preparation method comprises the steps of reacting 4-fluoro-alpha-methyl styrene (compound 2) ando-chlorohalobenzene in an organic solvent under the action of a catalyst and a base at 60-150 DEG C to obtain 1-(2-chlorophenyl)-2-(4-fluorophenyl)-1-propylene; reacting the 1-(2-chlorophenyl)-2-(4-fluorophenyl)-1-propylene and a brominating reagent in an organic solvent at 0-60 DEG C to obtain 1-(2-chlorophenyl)-2-(4-fluorophenyl)-3-bromo-1-propylene; and oxidizing and condensing the 1-(2-chlorophenyl)-2-(4-fluorophenyl)-3-bromo-1-propylene to synthesize the epoxiconazole. The method has the advantages of few steps, simple operation, good stereo selectivity, high yield, good atom economy andthe like, meets the requirements of safety and environmental protection, and is suitable for industrial production.

A catalytic air or oxygen gas ring method of oxidative synthesis of epoxiconazole

The invention belongs to the field of organic synthesis, and concretely relates to a method for synthesizing epoxiconazole by catalyzing air or oxygen epoxidation. Triazo alkene is epoxidized under the catalysis of a metal cobalt and iron organic catalyst with air or oxygen as an oxidant and aldehyde as an oxygen acceptor. A reaction formula is shown in the specification. The catalytic epoxidation reaction has the advantages of simple operation, high raw material conversion rate and high yield, and is suitable for the large scale preparation of epoxiconazole. In the formula, Cat represents the metal cobalt and iron organic catalyst.

FUNGICIDAL MIXTURES

The present invention relates to fungicidal mixtures comprising, as active components, 1) azolylmethyloxiranes of the general formula I wherein the variables have the meanings described in the application, 2) a fungicidal compound II, and 3) optionally a further fungicidal compound II, where the compounds II of components 2 and 3 independently of one another are selected from the group consisting of the compounds described in the application, with the proviso that components 2 and 3 are not identical, and to the use of the fungicidal mixtures for controlling phytopathogenic fungi and to the compositions comprising them.

FUNGICIDAL MIXTURES

The present invention relates to fungicidal mixtures comprising, as active components, 1) azolylmethyloxiranes of the general formula I in which the variables have the meanings described in the application, and 2) a fungicidal compound II, where the compounds II of component 2 are selected from among the compounds described in the application, and to the use of the fungicidal mixtures for controlling phytopathogenic fungi and to the compositions comprising them.

Synergistic Fungidical Active Substance Combinations

The present invention relates to novel active substance combinations which contain spiroxamine, which is known, a known azole and a known carboxamide and which are very suitable for controlling undesired phytopathogenic fungi.

Optically active 2,5-bisaryl-delta1-pyrrolines and their use as pest control agents

Novel optically active Δ1-pyrrolines of the formula (I) in which R1, R2, R1, R4, and m are each as defined in the description, a plurality of the processes for preparing these substances and their use for controlling pests.

Delta1-pyrrolines used as pesticides

Novel Δ1-pyrrolines of the formula (I) in which Ar1, Ar2 and Q are each as defined in the description, a plurality of processes for preparing these substances and their use for controlling pests.

Delta 1-pyrrolines used as pesticides

Novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, m and Q have the meanings given in the description, a plurality of processes for preparing these substances and their use for controlling pests.