135324-67-3

Upstream product

• 96583-92-5 6-amino-2-chloro-4-phenylpyridine-3,5-dicarbonitrile 
• 93516-34-8 N-acetyl-N-(3,5-dicyano-6-methoxy-4-phenyl-pyridin-2-yl)acetamide 

Downstream Products

• 135324-75-3 7-Acetyl-8-methyl-2-oxo-4-phenyl-1,2-dihydro-1,5,6,8a,9-pentaaza-fluorene-3-carbonitrile 
• 135324-72-0 8-Amino-2-oxo-4-phenyl-1,2-dihydro-1,5,6,8a,9-pentaaza-fluorene-3,7-dicarbonitrile 
• 135324-73-1 8-Hydroxy-2-oxo-4-phenyl-1,2-dihydro-1,5,6,8a,9-pentaaza-fluorene-3,7-dicarbonitrile 
• 135324-79-7 pyrido<3',2':4,5>pyrazolo<3,2-c>naphtho<2,1-e>-1,2,4-triazine 
• 135324-74-2 3-Cyano-8-methyl-2-oxo-4-phenyl-1,2-dihydro-1,5,6,8a,9-pentaaza-fluorene-7-carboxylic acid ethyl ester 
• 135324-84-4 9-cyano-3,4-dimethylcarboxylate-10-phenylthiopyrido<3',2':4,5>pyrazolo<3,2-c>-1,2,4-triazine-8(7H)-one 
• 1246269-34-0 C₁₉H₁₆N₆O₃ 
• 1246269-35-1 C₂₁H₁₈N₆O₄ 

Relevant academic research and scientific papers

Studies on the acetylation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine-5- carbonitrile derivatives

(Chemical Equation Presented) The acetylation reaction of the differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile derivatives 1-6 is reported. The structure of the resulting acetamides has been investigated and confirmed by analy

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors

The synthesis and biological evaluation of a number of differently substituted 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives are reported. From the inhibition results on a selection of disease-relevant protein kinases [IC50 (μM) DYRK1A = 11; CDK5 = 0.41; GSK-3 = 1.5] we have observed that 3,6-diamino-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (4) constitutes a potential new and simple lead compound in the search of drugs for the treatment of Alzheimer's disease.