13533-23-8

Upstream product

• 98-01-1 furfural 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 31136-77-3 (4-bromo-anilino)-furan-2-yl-acetonitrile 
• 865353-80-6 (4-bromo-phenyl)-(1-furan-2-yl-but-3-enyl)-amine 
• 865353-68-0 (4-bromo-phenyl)-(1-furan-2-yl-3-methyl-but-3-enyl)-amine 
• 33829-88-8 4-bromo-N-furfuryl-aniline 

Relevant academic research and scientific papers

Schiff base Cu(I) catalyst for aerobic oxidation of primary alcohols

We report here new copper(I)-Schiff base complexes for the selective oxidation of primary alcohols to aldehydes under ambient conditions (with 2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO), N-methylimidazole (NMI), ambient air, acetonitril and RT). Particularly, the copper(I) complex bearing N-(4-fluorophenyl)-1-(furan-2-yl)methanimine (L2) showed high activity in the series and gave near- quantitative yields in the oxidations of benzyl alcohol (99% yield in 1 h) and 1-octanol (96% yield in 24 h). Based on the X-ray structure determination, the complex has a square pyramidal coordination accomplished by two L2 ligands and bromide as a counter anion. The oxidation reactions were monitored with UV–vis and in situ ATR-IR spectroscopy to study the changes in the catalytic structure and to elucidate the catalytic properties and the mechanistic details. Accordingly, detachment of one of the L2 ligands from the complexes is related to the oxidation activity.

Sulfonic acid supported on hydroxyapatite-encapsulated-γ-Fe 2O3 nanocrystallites as a magnetically separable catalyst for one-pot reductive amination of carbonyl compounds

A novel, environmentally friendly procedure has been developed for the preparation of secondary or tertiary amines by one-pot reductive amination of carbonyl compounds using sodium borohydride in the presence of a magnetically recoverable sulfonic acid supported on hydroxyapatite-encapsulated-γ- Fe2O3 [γ-Fe2O3@HAP-SO 3H] at room temperature. The catalyst was easily separated from the reaction mixture by applying an external magnet and reused for six cycles without significant loss of catalytic activity.

Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment

Diverse N-substituted anilines bearing hetaryl fragments were easily prepared from corresponding aldimines derived from commercially available aromatic aldehydes and anilines. 2-Furyl substituted anilines showed very good antifungal activities against dermatophytes, particularly against Trichophyton rubrum (MIC = 3.12-6.25 μg/mL). In addition, all active compounds, 45-47, 73, and 74, were tested for cytotoxic activities against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines with the NCI-anticancer-drug screen. The activity of amines described in this paper, along with the low toxicity of most of them, shows promise for the future development of non-toxic new antimycotic agents.

An efficient synthesis of isoindolo[2,1-a]quinoline derivatives via imino Diels-Alder and intramolecular Diels-Alder reactions with furan

The straightforward synthesis of new isoindolo[2,1-a]quinoline derivatives from 2,4-disubstituted 1,2,3,4-tetrahydroquinolines bearing a furan fragment via the intramolecular Diels-Alder reaction is reported. The synthesis of key precursors was realized w

Novel approach to isoindolo[2,1-a]quinolines: Synthesis of 1- and 3-halo-substituted 11-oxo-5,6,6a,11-tetrahydroisoindolo[2,1-a]quinoline-10- carboxylic acids

A series of 1- and 3-halo-substituted isoindolo[2,1-a]quinolines were obtained by means of electrophilic cyclization of methallyl- and allyl-substituted isoindolo-7-carboxylic acids. The influence of halogen atoms on the stereochemistry of the formation o

Intramolecular Diels-Alder Reaction with Furans: Effect of the Substitution Pattern Reinvestigated

Intramolecular Diels-Alder reactions occurred smoothly when N-(α-cyanofurfuryl)arylamines 2a-g and N-furfurylarylamines 7a-d were treated with maleic anhydride and fumaroyl chloride-triethylamine respectively, to afford the corresponding cycloadducts 4 an

SYNTHESIS AND SPECTRAL PROPERTIES OF 1-ARYL-2-FORMYLPYRROLES

Various 1-aryl-2-formylpyrroles were synthesized by reaction of furfurol with substituted anilines.For p-bromo- and p-chlorophenyl substituents, the intermediate Schiff bases were isolated.