13533-31-8

Usage

Uses

Used in Pharmaceutical Industry:
4-chloro-N-[(E)-thiophen-2-ylmethylidene]aniline is used as a building block for the synthesis of various biologically active compounds. Its unique chemical structure allows it to be incorporated into the development of new drugs with potential therapeutic benefits.
Used in Agricultural Industry:
In the agricultural industry, 4-chloro-N-[(E)-thiophen-2-ylmethylidene]aniline is used as a building block for the synthesis of various agrochemicals. Its potential applications include the development of new pesticides, herbicides, and other crop protection agents.
Used as a Dye:
4-chloro-N-[(E)-thiophen-2-ylmethylidene]aniline has been studied for its potential applications as a dye due to its yellow to light brown color. It can be used in various industries that require coloration, such as textiles, plastics, and printing inks.
Used as an Indicator:
4-chloro-N-[(E)-thiophen-2-ylmethylidene]aniline has also been studied for its potential use as an indicator in various chemical reactions. Its unique chemical properties may allow it to change color or exhibit other visual changes in response to specific conditions, making it useful for monitoring reactions or detecting the presence of certain substances.
Used as a Corrosion Inhibitor:
4-chloro-N-[(E)-thiophen-2-ylmethylidene]aniline has been investigated for its potential as a corrosion inhibitor. Its chemical structure may provide protective properties against corrosion in various materials, making it useful in industries such as metal processing, construction, and automotive.
However, it is important to handle 4-chloro-N-[(E)-thiophen-2-ylmethylidene]aniline with care, as it can be harmful if inhaled, swallowed, or absorbed through the skin, and can cause irritation to the respiratory system and skin. Proper safety measures should be taken during its use and handling to minimize potential health risks.

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 55643-97-5 1-(4-chloro-phenyl)-5-thiophen-2-yl-4,5-dihydro-1H-[1,2,3]triazole 
• 65964-50-3 7-(trans-2-thiophen-2-yl-vinyl)-2-p-tolyl-imidazo[1,2-a]pyridine 
• 65964-49-0 2-(4-chloro-phenyl)-7-(trans-2-thiophen-2-yl-vinyl)-imidazo[1,2-a]pyridine 
• 65964-51-4 7-[(E)-2-thienylvinyl]-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine 
• 65964-52-5 2-biphenyl-4-yl-7-(trans-2-thiophen-2-yl-vinyl)-imidazo[1,2-a]pyridine 
• 38766-23-3 2-(4-chloro-phenyl)-5-methoxy-6-(2-thiophen-2-yl-vinyl)-2H-benzo[1,2,3]triazole 
• 65964-48-9 2-phenyl-7-(trans-2-thiophen-2-yl-vinyl)-imidazo[1,2-a]pyridine 
• 105090-49-1 1-(4-Chlorophenyl)-3,3-diphenyl-4-(2-thienyl)-2-azetidinone 
• 1000405-93-5 1-(4-chlorophenyl)-3,5-diphenyl-2-(thiophen-2-yl)-1H-pyrrole 
• 193601-78-4 Co(C₁₁H₈ClNS)2(H₂O)2⁽²⁺⁾*SO₄^(2-)*H₂O=Co(C₁₁H₈ClNS)2(H₂O)2(SO₄)*H₂O 
• 193601-91-1 Cu(C₁₁H₈ClNS)2(H₂O)2⁽²⁺⁾*SO₄^(2-)*H₂O=Cu(C₁₁H₈ClNS)2(H₂O)2(SO₄)*H₂O 

Relevant academic research and scientific papers

Synthesis of Green/Blue Light Emitting Quinolines by Aza-D-A Reaction Using InCl3 Catalyst

An efficient InCl3-catalyzed sequential reaction of aromatic amines, aromatic aldehydes and functionalized alkynes leading to the formation of new quinoline derivatives exhibiting significant fluorescence activities is described. The photophysi

A new catalytic approach for aerobic oxidation of primary alcohols based on a Copper(I)-thiophene carbaldimines

We report here novel Cu(I) thiophene carbaldimine catalysts for the selective aerobic oxidation of primary alcohols to their corresponding aldehydes and various diols to lactones or lactols. In the presence of the in situ generated Cu(I) species, a persistent radical (2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO)) and N-methylimidazole (NMI) as an auxiliary ligand, the reaction proceeds under aerobic conditions and at ambient temperature. Especially the catalytic system of 1-(thiophen-2-yl)-N-(4-(trifluoromethoxy)phenyl)methanimine (ligand L2) with copper(I)-iodide showed high reactivity for all kind of alcohols (benzylic, allylic and aliphatic). In the case of benzyl alcohol even 2.5 mol% of copper loading gave quantitative yield. Beside high activity under aerobic conditions, the catalysts ability to oxidize 1,5-pentadiol to the corresponding lactol (86% in 4 h) and N-phenyldiethanolamine to the corresponding morpholine derivate lactol (86% in 24 h) is particularly noteworthy.

Heterogeneous Catalysis with Basic Compounds to Achieve the Synthesis and C-N Cleavage of Azetidin-2-ones under Microwave Irradiation

The synthesis of azetidin-2-ones with a completely heterogeneous catalysis is reported. The use of basic compounds as solid catalysts allowed for the synthesis of azetidin-2-ones under microwave irradiation without organic additives such as triethylamine. An excellent catalyst for this transformation was Mg-Al hydroxide (MAH). The present methodology offers the advantages of non-hazardous reaction conditions, short reaction times, high yields, and catalyst reusability. Different substitution groups were tested on the imines and acyl chlorides to explore the scope of the reaction. Unconventional N-C4 bond cleavage was detected in azetidin-2-ones. MAH was characterized by N 2 adsorption-desorption, X-ray diffraction (XRD), scanning electron microscopy (SEM), and high-resolution transmission electron microscopy (HR-TEM).

Reactions of 2,2,6-Trimethyl-1,3-dioxin-4-one with the Aryl Aldimines Prepared from Thiophene-2-carbaldehyde

The reactions of aryl aldimines derived from thiophene-2-carbaldehyde (5–9) with 2,2,6-trimethyl-1,3-dioxin-4-one (1) were investigated. The new 1,3-oxazin-4-ones and thienylidene acetoacetamides were obtained in good yields. The synthetic utility of the latter via an intramolecular tandem Friedel–Crafts alkylation–acylation to give tetracyclic heterocyclic rings was also explored.

A simple method for the synthesis of 1,3-diaminopropan-2-ols derivatives and their ex vivo relaxant activity on isolated rat tracheal rings

Abstract: A mild and eco-friendly method has been developed for the synthesis of a series of 1,3-diaminopropan-2-ols 8a–n. The epoxide of epichlorohydrin undergoes ring-opening with amines using MgSO4 or mixed metal oxides catalysts under mild

Synthesis and photophysical properties of fluorescent arylstyrylimidazo[1,2-a]pyridine-based donor-acceptor chromophores

A series of novel fluorescent arylstyrylimidazo[1,2-a]pyridines was synthesized and fully characterized. All styryl derivatives have an E-configuration of the vinyl double bond as unequivocally shown by 1H NMR spectroscopy. It was observed that

Comparative study of conventional and microwave-assisted synthesis of some Schiff bases and their potential as antimicrobial agents

A series of Schiff bases (compounds 1-10) were synthesized by condensing heterocyclic/aromatic aldehydes with heterocyclic/aromatic amines through both, conventional method and microwave-assisted synthesis. The compounds were confirmed by means of IR spec

In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions

Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino Diels-Alder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds.

A novel four-component synthesis of N-substituted amino acid esters

A library of N-substituted amino acid esters was synthesized using a solid phase bound organic isocyanide that provides a C1 synthon to the final molecule. This novel four-component, one-pot reaction delivers the final products in acceptable yields with high purities of the crude reaction products, facilitating the final purification. The preparation of the isocyano resin is also described the intermediates being controlled by ATR-spectroscopy.