135330-86-8

Basic information

• Product Name: 1-[2-(2,4-dichlorophenyl)-2-{[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy}ethyl]-1H-imidazole
• CAS NO: 135330-86-8
• Molecular Formula: C₂₆H₃₄Cl₂N₂O
• Molecular Weight: 461.467
• Mol File: 135330-86-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 582°C at 760 mmHg
• Flash Point: 305.8°C
• Density: 1.07g/cm³
• Vapor Pressure: 6.3E-13mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 1-[2-(2,4-dichlorophenyl)-2-{[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy}ethyl]-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(2,4-dichlorophenyl)-2-{[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy}ethyl]-1H-imidazole(135330-86-8)
• EPA Substance Registry System: 1-[2-(2,4-dichlorophenyl)-2-{[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy}ethyl]-1H-imidazole(135330-86-8)

Safety Data

• Hazardous Substances Data: 135330-86-8(Hazardous Substances Data)

Upstream product

• 6784-45-8 (2E,6E)-farnesyl chloride 
• 24155-42-8 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol 

Relevant articles and documents

Structure-activity relationships of a new antifungal imidazole, AFK-108, and related compounds

Fungicidal activity of widely used imidazole antifungal drugs in topical applications is not so strong in spite of their potent fungistatic activities against dermatophytes and pathogenic yeasts. In order to improve fungicidal activity of imidazole antifungal agents, a series of novel imidazole derivatives having a hydrophobic substituent derived from isoprenoid were synthesized. The efficacy of these compounds was evaluated with respect to direct cell-membrane damaging activity, ergosterol biosynthesis inhibition, minimum growth-inhibitory concentration (MIC) and therapeutic effect for experimental dermatophytosis of guinea pigs. Among the newly synthesized compounds, the geranyl derivative named AFK-108 (2a) showed the highest in vivo fungicidal activity with both cell membrane damaging activity and ergosterol biosynthesis inhibition in vitro.