135340-48-6

Basic information

• Product Name: p-Tolyl-(2,4,6-trichloro-phenyl)-methanone
• Synonyms: p-Tolyl-(2,4,6-trichloro-phenyl)-methanone
• CAS NO: 135340-48-6
• Molecular Weight: 299.584
• Mol File: 135340-48-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: p-Tolyl-(2,4,6-trichloro-phenyl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: p-Tolyl-(2,4,6-trichloro-phenyl)-methanone(135340-48-6)
• EPA Substance Registry System: p-Tolyl-(2,4,6-trichloro-phenyl)-methanone(135340-48-6)

Safety Data

• Hazardous Substances Data: 135340-48-6(Hazardous Substances Data)

Upstream product

• 615-65-6 2-chloro-4-methyl-benzenamine 
• 135365-02-5 2-Bromo-6-chloro-4-methyl-benzoyl chloride 
• 135340-80-6 2-bromo-6-chloro-4-methylbenzamide 
• 135340-36-2 2-chloro-6-bromo-4-methylbenzoic acid 
• 135340-79-3 2-bromo-6-chloro-4-methylbenzonitrile 
• 135340-78-2 2-bromo-6-chloro-4-methylaniline 
• 4136-95-2 2,4,6-trichlorobenzoyl chloride 
• 108-88-3 toluene 

Downstream Products

• 135340-60-2 (4-Bromomethyl-phenyl)-(2,4,6-trichloro-phenyl)-methanone 
• 135340-83-9 (4-Azidomethyl-phenyl)-(2,4,6-trichloro-phenyl)-methanone 
• 135340-76-0 5-Amino-1-[4-(2,4,6-trichloro-benzoyl)-benzyl]-1H-[1,2,3]triazole-4-carboxylic acid amide 

Relevant articles and documents

Benzylated 1,2,3-triazoles as anticoccidiostats

Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s,v to 5a-s,v. In Scheme I, the brominated benzyl analogues 5 were converted to the corresponding benzyl azides 6, which were treated with cyanoacetamide to yield 1-substituted-5-amino-4-carbamoyl-1,2,3-triazoles 3. In Scheme II, the benzyl halides 5 were employed to alkylate the sodium salt of 5-amino-4-carbamoyl-1,2,3-triazole (7). Preliminary screening data against Eimeria acervulina and E. tenella in chickens suggested structural requirements for maximizing activity. Further evaluation against a relatively resistant series of eight Eimeria field isolates revealed L-651,582 (3a) to be a highly effective coccidiostat. However, unacceptable tissue residues precluded further development. Mechanistic studies on this series of 5-amino-4-carbamoyl-1,2,3-triazoles and, in particular, on L-651,582 (3a) revealed that its mode of action does not involve inhibition of IMP dehydrogenase, but probably interferes with host cell calcium entry. In addition, L-651,582 has been found to have antiproliferative activity in several disease models and was recently reported to possess antimetastatic activity in a model of ovarian cancer progression.