1353553-07-7

Basic information

• Product Name: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-
• Synonyms: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-;2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine
• CAS NO: 1353553-07-7
• Molecular Formula: C₁₂H₆ClN₃O₃S
• Molecular Weight: 307.71234
• EINECS: -0
• Mol File: 1353553-07-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-(1353553-07-7)
• EPA Substance Registry System: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-(1353553-07-7)

Safety Data

• Hazardous Substances Data: 1353553-07-7(Hazardous Substances Data)

Usage

General Description

Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)- is a chemical compound that belongs to the thieno[3,2-d]pyrimidine family. It is a derivative of thieno[3,2-d]pyrimidine with a chloro group at position 2 and a 3-nitrophenoxy group at position 4. Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)- has potential applications in pharmaceutical and agrochemical industries due to its structure and properties. It can be used as a building block in the synthesis of various biologically active compounds, such as potential drug candidates or agrochemicals. Additionally, its unique structure and functional groups make it a valuable intermediate in organic synthesis. However, further research and studies are necessary to fully explore and understand the potential uses and applications of this chemical.

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 16233-51-5 1H-thieno[3,2-d]pyrimidine-2,4-dione 
• 16234-14-3 2,4-dichlorothieno[3,2-d]pyrimidine 
• 554-84-7 meta-nitrophenol 

Downstream Products

• 1353553-11-3 N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidin-2-amine 

Relevant articles and documents

Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations

Five series of novel thiophene-pyrimidine derivatives (9a-h, 10a-f, 11a-f, 12a-f, 13a-f) have been synthesized and tested for their anti-proliferative activity against several cancer cell lines in which EGF is highly expressed. Most of the target compounds showed excellent activity against one or more cancer cell lines. The most promising compound 13a, of which IC50 values on of cell lines A549 and A431 (4.34 ± 0.60 μM and 3.79 ± 0.57 μM) were similar to the lead compound Olmutinib, showed strong activity and selectivity to EGFRT790M and EGFRT790M/L858R. Inhibition data of human normal hepatoma cell line LO2 indicated that most target compounds were less toxic to normal cells and had selective inhibitory effects on cancer cells. In addition, the structure-activity relationship was analyzed and the mechanism of apoptosis induced by the 13a was studied. The results showed that compound 13a induced late apoptosis of A431 cancer cells in a dose-dependent manner.

NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHD3ITION OF TYROSINE KINASE ACTIVITY

The present invention relates to a novel fused pyrimidine derivative having an inhibitory activity for tyrosine kinases, and a pharmaceutical composition for preventing or treating cancers, tumors, inflammatory diseases, autoimmune diseases, or immunologically mediated diseases comprising same as an active ingredient.