1353553-07-7

Basic information

• Product Name: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-
• Synonyms: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-;2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine
• CAS NO: 1353553-07-7
• Molecular Formula: C₁₂H₆ClN₃O₃S
• Molecular Weight: 307.71234
• EINECS: -0
• Mol File: 1353553-07-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-(1353553-07-7)
• EPA Substance Registry System: Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-(1353553-07-7)

Safety Data

• Hazardous Substances Data: 1353553-07-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)is used as a building block for the synthesis of potential drug candidates. Its unique structure and functional groups allow for the development of compounds with specific biological activities, making it a promising candidate for the creation of new pharmaceuticals.
Used in Agrochemical Industry:
In the agrochemical industry, Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)is utilized as a precursor for the synthesis of agrochemicals. Its properties and structure enable the production of compounds with pesticidal or herbicidal activities, contributing to the development of effective crop protection agents.
Used in Organic Synthesis:
Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)serves as a valuable intermediate in organic synthesis. Its functional groups and structural features facilitate the synthesis of a wide range of organic compounds, making it a versatile building block for various chemical reactions and applications.
However, it is important to note that further research and studies are necessary to fully explore and understand the potential uses and applications of Thieno[3,2-d]pyrimidine, 2-chloro-4-(3-nitrophenoxy)-. This will help in optimizing its synthesis, improving its properties, and expanding its applications across different industries.

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 16233-51-5 1H-thieno[3,2-d]pyrimidine-2,4-dione 
• 16234-14-3 2,4-dichlorothieno[3,2-d]pyrimidine 
• 554-84-7 meta-nitrophenol 

Downstream Products

• 1353553-11-3 N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidin-2-amine 

Relevant articles and documents

Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations

Five series of novel thiophene-pyrimidine derivatives (9a-h, 10a-f, 11a-f, 12a-f, 13a-f) have been synthesized and tested for their anti-proliferative activity against several cancer cell lines in which EGF is highly expressed. Most of the target compounds showed excellent activity against one or more cancer cell lines. The most promising compound 13a, of which IC50 values on of cell lines A549 and A431 (4.34 ± 0.60 μM and 3.79 ± 0.57 μM) were similar to the lead compound Olmutinib, showed strong activity and selectivity to EGFRT790M and EGFRT790M/L858R. Inhibition data of human normal hepatoma cell line LO2 indicated that most target compounds were less toxic to normal cells and had selective inhibitory effects on cancer cells. In addition, the structure-activity relationship was analyzed and the mechanism of apoptosis induced by the 13a was studied. The results showed that compound 13a induced late apoptosis of A431 cancer cells in a dose-dependent manner.

Synthesis and biological activity of imidazole group-substituted arylaminopyrimidines (IAAPs) as potent BTK inhibitors against B-cell lymphoma and AML

Bruton's tyrosine kinase (BTK) is a member of the Tec kinase family and plays a key role in the modulation of the B-cell receptor (BCR)-mediated signaling pathway. Inhibition of BTK has been proven to be an effective therapeutic approach for various hemat

NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHD3ITION OF TYROSINE KINASE ACTIVITY

The present invention relates to a novel fused pyrimidine derivative having an inhibitory activity for tyrosine kinases, and a pharmaceutical composition for preventing or treating cancers, tumors, inflammatory diseases, autoimmune diseases, or immunologically mediated diseases comprising same as an active ingredient.