135357-56-1Relevant academic research and scientific papers
Reaction of N-substituted exo-2-hydroxy-5-oxo-4-oxatricyclo[4.2.1.0 3,7]nonane-endo-9-carboxamides with acetic acid
Pal'Chikov,Tarabara,Omel'Chenko,Shishkin,Kas'Yan
experimental part, p. 823 - 829 (2010/10/19)
Acylation of N-substituted exo-2-hydroxy-5-oxo-4-oxatricyclo[4.2.1.0 3,7]nonane-endo-9-carboxamides on heating in boiling glacial acetic acid gave the corresponding trans-diacetoxy imides of the norbornane series. The effect of the reaction tim
Lactonation of N-alkyl-and N,N-dialkylamido acids of norbornene series in reactions with performic acid
Pal'chikov,Tarabara,Shishkina,Shishkin,Kol'tsov,Kas'yan
, p. 660 - 673 (2008/02/08)
Reaction products were obtained from bicyclo[2.2.1]hept-5-ene-endo,endo-2, 3-dicarboxylic (endic) acid anhydride and ammonia, methyl-, benzyl-, dimethyl-, methylbenzyl-, dibenzyl-, diethyl-, dipropyl-, diisopropyl-, and dipentylamines. The synthesized ami
Lactonization of epoxyendic anhydride in reactions with amines
Kas'yan,Krishchik,Tarabara,Kas'yan,Pal'chikov
, p. 501 - 508 (2007/10/03)
Reactions of exo-5,6-epoxybicyclo[2.2.1]hept-5-ene-endo-2,endo-3- dicarboxylic anhydride (epoxyendic anhydride) with acyclic, aromatic, heteroaromatic, and nonaromatic heterocyclic amines afforded the corresponding heterocyclization products, substituted
Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists
Kiesman, William F.,Zhao, Jin,Conlon, Patrick R.,Petter, Russell C.,Jin, Xiaowei,Smits, Glenn,Lutterodt, Frank,Sullivan, Gail W.,Linden, Joel
, p. 3654 - 3661 (2007/10/03)
During the search for second-generation adenosine A1 receptor antagonist alternatives to the clinical candidate 8-(3-oxa-tricyclo[3.2.1.02,4]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (BG9719), we developed a series of novel xanthines substituted with norbornyl-lactones that possessed high binding affinities for adenosine A1 receptors and in vivo activity.
Epoxidation of bicyclo[2.2.1]hept-5-ene-2,3-endo- and exodicarboxylic acid N-arylimides
Salakhov,Bagmanova
, p. 244 - 247 (2007/10/03)
Epoxidation of endo- and exo-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid N-arylimides with a solution of peracetic acid in anhydrous dioxane affords 5,6-exo-epoxybicycloheptanedicarboxylic acid N-arylimides. The epoxidation reaction is not sensitive to
Enzymatic optical resolution of norbornanecarboxylic esters using Pig Liver Esterase
Gastel, F. J. C. van,Klunder, A. J. H.,Zwanenburg, B.
, p. 175 - 184 (2007/10/02)
The hydrolysis of a series of norbornane-type carboxylic esters catalyzed by pig liver esterase (PLE) has been investigated.It was found that an exo-ester function (syn to the C7 methylene group) is hydrolyzed with high preference.Enantioselective hydrolysis can be accomplished when a vicinal carbonyl-containing function (ester, formyl, acetyl) is present in a trans position with respect to the exo ester.The regiospecifity of the enzymatic hydrolysis has been used for the separation of exo/endo mixtures of the cycloadducts derived from cyclopentadiene and alkene esters.The regiospecifity and enantioselectivity of the enzymatic hydrolysis of norbornane-type esters were analyzed in terms of Tamm's substrate model and also by Griengl's method.
STRUCTURAL REQUIREMENTS IN THE ENZYMIC OPTICAL RESOLUTION OF BICYCLIC ESTERS USING PIG LIVER ESTERASE
Klunder, A. J. H.,Gastel, F. J. C. van,Zwanenburg, B.
, p. 2697 - 2700 (2007/10/02)
The PLE-catalyzed hydrolysis of bicyclic mono- and diesters 4-15 have been studied.Structural features such as bridge size and relative configuration of the ester functions have found to be essential for effective hydrolysis.A high degree of stereo- and enantioselectivity was observed for trans-bicycloheptane-2,3-diesters 4, 5 and 6.
A NEW HYDROXY-LACTONIZATION OF OLEFINIC ACIDS
Hendrickson, James B.,Singh, Vishwakarma
, p. 431 - 434 (2007/10/02)
Bicyclic olefin acids afford trans-hydroxy-lactones with aqueous calcium hypochlorite.Monocyclic and acyclic olefin acids yield mainly the corresponding (opened) dihydroxy acids.
