135358-19-9

Upstream product

• 6318-30-5 2,2-dimethyl-4-(3-hydroxypropyl)-1,3-dioxolane 
• 98-59-9 p-toluenesulfonyl chloride 
• 173152-84-6 ethyl (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionate 
• 917877-01-1 R-3-(2,2-dimethyl[1,3]dioxolan-4-yl)-acrylic acid ethyl ester 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 22323-80-4 (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 5470-86-0 1,2,5-triacetoxypentane 
• 14697-46-2 1,2,5-pentanetriol 

Downstream Products

• 104121-24-6 (+/-)-2-amino-6-benzyloxy-9-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)propyl]purine 
• 51154-96-2 (R)-massoialactone 
• 110549-07-0 (R)-1,2-epoxyheptane 
• 78843-64-8 (2R)-heptane-1,2-diol 
• 177411-59-5 5-Benzylsulfanyl-pentane-1,2-diol 
• 197365-59-6 1-(pent-4-en-1-yl)-1H-pyrrole 
• 106681-49-6 5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate 
• 177411-58-4 4-(3-Benzylsulfanyl-propyl)-2,2-dimethyl-[1,3]dioxolane 

Relevant academic research and scientific papers

MONOBACTAM COMPOUNDS AND USE THEREFOR

Monobactam compounds and a use therefor. Specifically provided are chemical compounds represented by formula (I) or isomers, pharmaceutically acceptable salts, solvates, crystals, or prodrugs thereof, preparation methods therefor, pharmaceutical compositions containing said compounds, and a use of said compounds or compositions in treating bacterial infection. The present compounds feature excellent antibacterial activity, and have great hopes of becoming a therapeutic agent for bacterial infection.

A synthesis of (-)-tashiromine and formal synthesis of (+)-tashiromine utilizing a highly enantioselective pyrrole/cobaloxime π-cation cyclization

Cyclization of (5-N-pyrrolyl-2-hydroxypentyl)cobaloxime (13) proceeds by intramolecular electrophilic aromatic substitution of a cobaloxime π-cation onto the pyrrole ring to provide 6-exo cyclization product (14) in 95% yield. This cyclization is highly enantioselective. It is applied to a synthesis of highly enantioenriched (-)-tashiromine, (-)-21, and a formal synthesis of (+)-tashiromine.

Remarkably selective Ag+ extraction and transport by thiolariat ethers

Synthesis and metal binding properties of thiolariat ethers, where a sulfide side chain is introduced into a framework of a crown ether, have been performed. Remarkably high Ag+ selectivity among heavy metal ions was observed in solvent extraction and transport across a liquid membrane using thiolariat ethers with a 15-crown-5 ring as carriers. Thiolariat ethers with a 12-crown-4 or a 18-crown-6 do not exhibit such a high Ag+ selectivity. The former binds metal ions weakly, and the latter recognizes Pb2+ as well as Ag+. The corresponding oxygen analogs, i.e. lariat ethers, do not show Ag+ selectivity. The Ag+ binding strength of the sulfoxide and sulfone analogs is much lower than that of thiolariat ethers. Thiolariat ethers with a benzocrown framework containing a sulfide chain at the 4 position of the benzene nucleus showed very low affinity to Ag+. Extractability and transport ability using various thiolariat ether derivatives strongly suggested that this high Ag+ selectivity is a result of the synergistic coordination of the ring oxygen and the sulfur atom of the thiolariat ether. NMR chemical shifts of protons and carbons in the proximity of the sulfur atom of the thiolariat ether were changed significantly in accordance with the synergistic coordination described above. 1:1 Complexation between a thiolariat ether and Ag+ were supported by a Job plot using the chemical shift of the methylene protons adjacent to the sulfur atom.

Antiviral compounds

4-(Guanin-9-yl)butanals and their 3-oxa, 3-thia, and 2-ene counterparts and derivatives thereof, wherein the aldehyde is protected, which have antiviral activity, and are useful in treating viral infections, particularly herpes viral infections, such as h

Pyrroles as Terminators in Cationic Cyclizations. The Preparation of 5,6,7,8-Tetrahydroindolizidines and 6,7,8,9-Tetrahydro-5H-pyrroloazepines

N-(Epoxyalkyl)pyrroles 8-13 are readily prepared either by direct pyrrole N-alkylation with either ω-iodo epoxides or ω-iodo-1,2-alkanediol acetonides followed by conversion to the corresponding epoxides.The cyclizations of these N-(epoxyalkyl)pyrroles were examined with a range of Lewis acids providing cyclized products 14 and 16-21 in moderate to excellent yields.The cyclization products 14, 16, and 20 are formally the products of "anti-Markovnikov" attack on the less substituted epoxide terminus.