5470-86-0

Basic information

• Product Name: 1,2,5-Trihydroxypentane
• Synonyms: Nsc27994;1,5-diacetyloxypentan-2-yl acetate
• CAS NO: 5470-86-0
• Molecular Formula: C₁₁H₁₈O₆
• Molecular Weight: 246.26
• Mol File: 5470-86-0.mol

Chemical Properties

• Boiling Point: 314.5°C at 760 mmHg
• Flash Point: 134.7°C
• Appearance: /
• Density: 1.114g/cm³
• Vapor Pressure: 0.000465mmHg at 25°C
• Refractive Index: 1.44
• CAS DataBase Reference: 1,2,5-Trihydroxypentane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Trihydroxypentane(5470-86-0)
• EPA Substance Registry System: 1,2,5-Trihydroxypentane(5470-86-0)

Safety Data

• Hazardous Substances Data: 5470-86-0(Hazardous Substances Data)

Usage

Type of compound

Sugar alcohol (polyol)

Appearance

White, odorless, crystalline powder

Natural occurrence

Found in fruits (pears, grapes), fermented foods, and beverages

Usage

Low-calorie sweetener in food and beverages (sugar-free candies, chewing gum, diet drinks)

Calorie content

Low

Effect on blood sugar levels

Does not affect

Suitability

For people with diabetes or those looking to reduce sugar consumption

Taste

Sweet, similar to table sugar

Popularity

Widely used for sugar reduction in diet-conscious individuals

InChI:InChI=1/C11H18O6/c1-8(12)15-6-4-5-11(17-10(3)14)7-16-9(2)13/h11H,4-7H2,1-3H3

Upstream product

• 55094-99-0 (–)-(S)-diethyl 2-hydroxyglutarate 
• 59287-66-0 4,5-dibromo-1-pentanol 
• 127-08-2 potassium acetate 
• 108-24-7 acetic anhydride 
• 28885-22-5 1,2,5-tribromopentane 
• 97-99-4 Tetrahydrofurfuryl alcohol 
• 75-36-5 acetyl chloride 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 13095-48-2 L-hydroxyglutaric acid 
• 55094-97-8 (S)-dimethyl 2-hydroxypentanedioate 

Downstream Products

• 197365-59-6 1-(pent-4-en-1-yl)-1H-pyrrole 
• 106681-49-6 5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate 
• 69380-64-9 rac-2,2-dimethyl-4-(3'-hydroxypropyl)-1,3-dioxolan toluene-p-sulphonate 
• 6318-30-5 2,2-dimethyl-4-(3-hydroxypropyl)-1,3-dioxolane 
• 14697-46-2 1,2,5-pentanetriol 

Relevant articles and documents

Ring opening of cyclic ethers by sulfuric acid - Acetic anhydride

Cyclic ethers such as tetrahydrofuran or tetrahydropyran were easily cleaved at room temperature by sulfuric acid - acetic anhydride providing the corresponding diacetoxyalkanes in good yield. The ring opening was applicable to saturated cyclic ethers, regardless of the presence of substituent groups.

A synthesis of (-)-tashiromine and formal synthesis of (+)-tashiromine utilizing a highly enantioselective pyrrole/cobaloxime π-cation cyclization

Cyclization of (5-N-pyrrolyl-2-hydroxypentyl)cobaloxime (13) proceeds by intramolecular electrophilic aromatic substitution of a cobaloxime π-cation onto the pyrrole ring to provide 6-exo cyclization product (14) in 95% yield. This cyclization is highly enantioselective. It is applied to a synthesis of highly enantioenriched (-)-tashiromine, (-)-21, and a formal synthesis of (+)-tashiromine.