1353634-75-9Relevant academic research and scientific papers
PYRIDINYLPYRAZOLES FOR USE AS KINASE MODULATORS FOR THE TREATMENT OF CANCER
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Page/Page column 30; 31, (2013/04/13)
Compounds of the substituted pyrazole class of Formula (I) as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases is described. Said method is effective and can be provided in
Tri- and tetrasubstituted pyrazole derivates: Regioisomerism switches activity from p38MAP kinase to important cancer kinases
Thaher, Bassam Abu,Arnsmann, Martina,Totzke, Frank,Ehlert, Jan E.,Kubbutat, Michael H. G.,Sch?chtele, Christoph,Zimmermann, Markus O.,Koch, Pierre,Boeckler, Frank M.,Laufer, Stefan A.
, p. 961 - 965 (2012/03/10)
In the course of searching for new p38α MAP kinase inhibitors, we found that the regioisomeric switch from 3-(4-fluorophenyl)-4-(pyridin-4-yl)-1- (aryl)-1H-pyrazol-5-amine to 4-(4-fluorophenyl)-3-(pyridin-4-yl)-1-(aryl)-1H- pyrazol-5-amine led to an almos
