1353639-65-2Relevant academic research and scientific papers
Synthesis and cytotoxicity evaluation of phosphorylated derivatives of ribavirin
Rao, Valasani Koteswara,Reddy, Sanapalli Subba,Babu, Kilaru Raveendra,Kumar, Kuntrapakam Hema,Ghosh, Sunil Kumar,Raju, Chamarthi Naga
experimental part, p. 952 - 959 (2012/02/15)
Novel phosphorylated derivatives of ribavirin 5-16 were synthesized by the reaction of 4-nitrophenyl phosphorodichloridate with various amino acid esters in the presence of triethylamine in dry tetrahydrofuran through the intermediates 3. On further reaction of 3 with ribavirin in THF and pyridine in the presence of TEA afforded the title compounds 5-16. Their structures were characterized by IR, 1H, 13C, 31P NMR and mass spectral analyses. All the title compounds were found to exhibit potent in vitro anticancer activity against MCF-7 breast cancer cell lines.
