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High purity Ribavirin
Cas No: 36791-04-5
No Data 1 Kilogram 1500 Metric Ton/Year Siwei Development Group Ltd. Contact Supplier
Cas No: 36791-04-5
No Data No Data No Data SJZ THLD IMP & EXP CO LTD Contact Supplier
Ribavirin Manufacturer/High quality/Best price/In stock
Cas No: 36791-04-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity ribavirin with high quality and best price cas:36791-04-5
Cas No: 36791-04-5
USD $ 50.0-70.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Lidocaine hydrochloride injection 5ml/100mg;10ml/200mg
Cas No: 36791-04-5
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Factory supply Ribavirin
Cas No: 36791-04-5
USD $ 1.0-2.0 / Metric Ton 1 Metric Ton 500 Metric Ton/Week Hebei yanxi chemical co.,LTD. Contact Supplier
99% USP Ribavirin Cas 36791-04-5 with high quality and competitive price
Cas No: 36791-04-5
No Data 25 Kilogram 40 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
36791-04-5 Ribavirin
Cas No: 36791-04-5
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Ribavirin Cas No. 36791-04-5
Cas No: 36791-04-5
No Data 25 Kilogram 10000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
CHemwill -- Ribavirin
Cas No: 36791-04-5
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier

36791-04-5 Usage

General Description

White powder. Exists in two polymorphic forms.

Air & Water Reactions

Water soluble.


anti-infective, anti-fungal

Brand name

Copegus (Roche); Rebetol (Schering); Virazole (Valeant).

Reactivity Profile

Ribavirin may be sensitive to prolonged exposure to light.

Production method

Take nucleotide or nucleoside as the starting material
First hydrolyze the guanosine and guanylate upon the action of glacial acetic acid and acetic anhydride to generate ribose-1-phosphate, which is then subject to the catalysis of double-para-nitro phenol to have reaction with triazide amide to generate condensate with aminolysis to obtain the product.
Guanosine (or guanylate) [acetic anhydride, glacial acetic acid]→[hydrolysis] ribose-1-phosphate [bis-(p-nitrophenol)-phosphate]→[triazide carboxamide] condensates [aminolysis]→Ribavirin
Enzymatic synthesis
First hydrolyze the guanosine and guanosine acid under the action of pyrimidine nucleoside phosphorylase to form ribose-1-phosphate which then, under the action of purine nucleoside phosphorylase, has reaction with triazide amide to directly generate triazole nucleosides.
Guanosine (or guanylate) [pyrimidine nucleoside phosphorylase] → ribose-1 nucleic acid [purine nucleotide cyclase] → Ribavirin.

Chemical Properties

Colourless Solid


Ribavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza. It acts as a prodrug that can be activated by either mono- or tri-phosphorylation by cellular kinases. These phosphorylated derivatives of ribavirin have diverse effects on both cellular and viral enzymes, resulting in suppression of viral replication.

Pharmacological effects

1, Ribavirin can be subject to phosphorylation in red blood cells to generate ribavirin monophosphate, diphosphate and triphosphate, wherein the ribavirin monophosphate is the strong inhibitor of the inosine monophosphate dehydrogenase which can inhibit cellular guanylate synthesis, decrease the tri-phosphorylation of the intracellular guanylate triphosphate, and blocking the synthesis of viral nucleic acid.
2, ribavirin triphosphate can inhibit the influenza virus RNA polymerase and interfere with viral replication.
3, ribavirin triphosphate can inhibit the synthesis of viral mRNA 5 'end and transcriptase, thereby inhibiting the DNA and RNA synthesis. It has inhibitory effect on various kinds of viruses (including DNA viruses and RNA viruses). It also has prevention and treatment effect on the influenza, adenovirus pneumonia, hepatitis, herpes, and measles and is also effective on treating the epidemic hemorrhagic fever.
4, it is mainly excreted through urine in the prototype with also a small amount of de-sugarized ribavirin metabolites with a small amount discharged from the feces.
The above information is edited by the Chemicalbook of Dai Xiongfeng.


ChEBI: A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. An inhibitor of HCV polymerase.

Fire Hazard

Flash point data for Ribavirin are not available; however, Ribavirin is probably combustible.

Chemical Properties

This product is colorless or white crystalline powder and is odorless with no taste. It is stable in room temperature. It is easily soluble in water and slightly soluble in ethanol, chloroform and ether. It has its mp being 174-176 ℃ or 160-167 ℃ (refined products include two crystals).


Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.


A broad spectrum antiviral nucleoside and inhibitor of inosine monophosphate dehydrogenase.


aldosterone antagonist; antifibrogenic

Antiviral drugs

Ribavirin is a novel non-selective nucleoside class broad-spectrum antiviral drug, belonging to the inosine monophosphate (IMP) dehydrogenase inhibitor. It can participate in the guanine participate in the human body metabolism, interfere with the biosynthesis of guanine, prevent the replication of the virus and has inhibitory effect on a variety of DNA and RNA viruses. Ribavirin has a stronger antiviral effect than amantadine and vidarabine, etc with definite efficacy and small drug side effects. Rare adverse reactions include conjunctivitis and hypotension with the former exhibiting as intraocular foreign body sensation, photophobia, itching, swelling and hematoma and the latter manifested as blurred vision, dizziness, and fatigue. It is used for clinical treatment of viral upper respiratory tract infection, respiratory syncytial virus-induced viral pneumonia and bronchitis, influenza, para-influenza, epidemic encephalris, mumps, chickenpox, shingles, herpes zoster, autumn diarrhea, children early-stage adenovirus pneumonia, acute Lassa fever, rubella, viral pneumonia, genital herpes, herpes simplex virus keratitis, psoriasis, etc with special efficacy. It also have certain efficacy on treating epidemic hemorrhagic fever, hepatitis B, and hepatitis A. Applying this drug in early stage of epidemic hemorrhagic fever can shorten the period, reducing the damage of kidney and vascular and symptoms of poisoning.


It is a kind of broad-spectrum antiviral drugs for treating influenza (influenza A and B viruses), adenovirus pneumonia, hepatitis, herpes, measles with prevention and treatment effect; it is also effective on treating the epidemic hemorrhagic fever, particularly effective treatment of patients in their early stages. Oral administration can cause diarrhea without other significant toxicity but may cause neutropenia. Large dose can inhibit the maturation of hemoglobin and red blood cells, causing reversible anemia. There have been reports regarding to the teratogenicity and embryo toxicity in animal experiments. Pregnant women should be hanged.
Ribavirin is a broad-spectrum antiviral nucleoside drug used for treating influenza, adenovirus pneumonia of children, viral hepatitis, respiratory syncytial virus infection, acute keratitis, conjunctivitis, epidemic hemorrhagic fever and herpes zoster.

36791-04-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1602706)  Ribavirin  United States Pharmacopeia (USP) Reference Standard 36791-04-5 1602706-200MG 8,605.35CNY Detail
Sigma-Aldrich (Y0000377)  Ribavirin  European Pharmacopoeia (EP) Reference Standard 36791-04-5 Y0000377-2EA 1,880.19CNY Detail
TCI America (R0077)  Ribavirin  >98.0%(HPLC)(N) 36791-04-5 500mg 980.00CNY Detail
TCI America (R0077)  Ribavirin  >98.0%(HPLC)(N) 36791-04-5 100mg 320.00CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name ribavirin

1.2 Other means of identification

Product number -
Other names RTC

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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