1353680-07-5Relevant academic research and scientific papers
Highly efficient desilylation of 3-trimethylsilylprop-2-ynamides by the action of KF-Al2O3
Andreev,Safronova,Medvedeva
, p. 1797 - 1801 (2011)
A highly effective procedure has been developed for desilylation of 3-trimethylsilylprop-2-ynamides in the presence of KF-Al2O 3 as catalyst. The corresponding terminal prop-2-ynamides were obtained in high yield in methanol at 25°C using 5 mol % of the catalyst (reaction time 20 min). Rise in temperature leads to the formation of Z,E-3-methoxyprop-2-enamides or 3,3-dimethoxypropanamides as a result of tandem desilylation-addition of methanol, depending on the conditions.
