1353741-35-1

Basic information

• Product Name: (S)-5,5,5-trifluoro-4-(4-(trifluoromethyl)phenyl)-4-hydroxypentan-2-one
• Synonyms: (S)-5,5,5-trifluoro-4-(4-(trifluoromethyl)phenyl)-4-hydroxypentan-2-one
• CAS NO: 1353741-35-1
• Molecular Weight: 300.201
• Mol File: 1353741-35-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-5,5,5-trifluoro-4-(4-(trifluoromethyl)phenyl)-4-hydroxypentan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5,5,5-trifluoro-4-(4-(trifluoromethyl)phenyl)-4-hydroxypentan-2-one(1353741-35-1)
• EPA Substance Registry System: (S)-5,5,5-trifluoro-4-(4-(trifluoromethyl)phenyl)-4-hydroxypentan-2-one(1353741-35-1)

Safety Data

• Hazardous Substances Data: 1353741-35-1(Hazardous Substances Data)

Upstream product

• 74853-66-0 4'-trifluoromethyl-2,2,2-trifluoroacetophenone 
• 67-64-1 acetone 

Relevant articles and documents

Highly enantioselective immobilized prolinamide-catalyzed aldol reactions in continuous-flow systems: effect of water on the catalyst lifetime and application in the synthesis of a chiral fenpentadiol analogue

Catalytic enantioselective aldol reactions of trifluoroacetophenones with ketones under continuous-flow conditions have been developed for the first time by using polystyrene-supported prolinamides. The robustness of the flow system was demonstrated by the continuous synthesis of a variety of trifluoromethyl carbinols in high yields with high enantioselectivities. The unusually long lifetimes (>195 h) of this flow process were achieved by facilitating H2O-promoted hydrolysis of iminium intermediates on the polymer. Mechanistic study revealed a racemization phenomenon and an inherent reversible property of the aldol reactions in a conventional batch system, both of which were suppressed under continuous-flow conditions. The synthetic utility of this flow process was further demonstrated by the formal continuous-flow synthesis of a chiral fenpentadiol analogue.

Construction of tertiary alcohols bearing perfluoroalkyl chains catalyzed by prolinamide-thioureas

A systematic study to evaluate the ability of various organocatalysts to catalyze the aldol reaction between acetone and 2,2,2-trifluoromethyl-1- phenylethanone was undertaken. Benchmark organocatalysts failed to catalyzethis reaction. However, a prolinam