1353763-41-3Relevant academic research and scientific papers
Diphenyl phosphate creatine immobilized on magnetite nanoparticles: an efficient and recyclable catalyst for Aza-Michael reaction
Pazoki, Farzane,Mohammadpanah, Fahimeh,Salamat Manesh, Arefe,Azarnia Mehraban, Jamshid,Heydari, Akbar
, (2020)
Abstract: In this paper, diphenyl phosphate creatine was successfully immobilized on Fe3O4 nanoparticles and used as the highly efficient catalyst for the aza-Michael reaction of 5-substituted tetrazole and α,β-unsaturated carbonyl.
E-factor minimized protocols for the polystyryl-BEMP catalyzed conjugate additions of various nucleophiles to α,β-unsaturated carbonyl compounds
Bonollo, Simona,Lanari, Daniela,Longo, Julie M.,Vaccaro, Luigi
supporting information; experimental part, p. 164 - 169 (2012/04/04)
Efficient protocols for the addition of carbon-, sulphur- and nitrogen-nucleophiles to α,β-unsaturated carbonyl compounds catalyzed by PS-BEMP have been reported. The adoption of solvent-free conditions (SolFC) was crucial for improving the efficiency of all the processes, while by using an organic reaction medium poor results were obtained. Addition reactions were performed by using equimolar amounts of reagents, and the products were isolated by simple filtration with the minimal amount of organic solvent. This approach allowed the E-factor, a measure of the waste of a reaction, to be minimized. Further waste minimization (95.7% compared to batch protocol) has been accomplished by defining a larger scale continuous-flow protocol operating under SolFC.
