1353883-03-0

Basic information

• Product Name: (Z)-N-(1-(2-(4-chlorophenyl)-1H-indol-1-yl)-2,2,2-trifluoroethylidene)-1-phenylmethanamine
• Synonyms: (Z)-N-(1-(2-(4-chlorophenyl)-1H-indol-1-yl)-2,2,2-trifluoroethylidene)-1-phenylmethanamine
• CAS NO: 1353883-03-0
• Molecular Weight: 412.842
• Mol File: 1353883-03-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-N-(1-(2-(4-chlorophenyl)-1H-indol-1-yl)-2,2,2-trifluoroethylidene)-1-phenylmethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-(1-(2-(4-chlorophenyl)-1H-indol-1-yl)-2,2,2-trifluoroethylidene)-1-phenylmethanamine(1353883-03-0)
• EPA Substance Registry System: (Z)-N-(1-(2-(4-chlorophenyl)-1H-indol-1-yl)-2,2,2-trifluoroethylidene)-1-phenylmethanamine(1353883-03-0)

Safety Data

• Hazardous Substances Data: 1353883-03-0(Hazardous Substances Data)

Upstream product

• 1353882-74-2 N-benzyl-N'-(2-((4-chlorophenyl)ethynyl)phenyl)-2,2,2-trifluoroacetimidamide 
• 1353883-57-4 C₁₆H₈Cl₂F₃N 
• 100-46-9 benzylamine 
• 221910-19-6 2-(4-chlorophenylethynyl)phenylamine 

Relevant articles and documents

A detailed study of the intramolecular hydroamination of N-(ortho-alkynyl)aryl-N′-substituted trifluoroacetamidines and bromodifluoroacetamidines

The intramolecular hydroamination of N-(ortho-alkynyl)aryl-N′- substituted trifluoroacetamidines and bromodifluoroacetamidines is studied in detail. When the substituents on the alkyne fragment are aryl and alkyl groups, 5-endo-dig cyclization occurs utilizing NaAuCl4·2H 2O as a catalyst, while 6-exo-dig cyclization proceeds in the presence of K2CO3 as a base. Interestingly, the indole derivatives are afforded with good regioselectivity via a 5-endo-dig pathway catalyzed by Cu(OAc)2 when ortho-ethynyl appears on the aryl substituent of the amidine. The electrophilic cyclization of the amidines also shows good regioselectivity under the I2/NaHCO3 system. At the end, a facile cascade synthesis of fluorinated quinazolones is described via hydroamination/ozonolysis from the corresponding amidine.