135391-17-2

Upstream product

• 111-82-0 methyl n-dodecanoate 
• 95-54-5 1,2-diamino-benzene 
• 106-33-2 ethyl laurate 
• 143-07-7 lauric acid 
• 112-16-3 n-dodecanoyl chloride 

Relevant academic research and scientific papers

Solvent-effects tuning the catalytic reactivity of prolinamides in asymmetric aldol reactions

Novel prolinamides were prepared and applied as organocatalysts in the asymmetric aldol reaction. Stable imidazolidinones were formed between prolinamides and aromatic aldehydes in organic solvents. It was found that aqueous conditions can significantly suppress the formation of the unwanted imidazolidinone intermediate and improve the catalytic activity of the prolinamides. As a consequence, high chemical yields (up to 99%) and good diastereoselectivity (up to >20:1 dr) and enantioselectivity (up to 95% ee) were achieved in 2-Me-THF or brine. This strategy could serve as a general solution to enhance the performance of prolinamides as organocatalysts.

Enzyme-mediated domino synthesis of 2-alkylbenzimidazoles in solvent-free system: A green route to heterocyclic compound

Solvent-free domino acylation/cyclization reactions between fatty acid esters and o-phenylenediamine mediated by immobilized lipase from Mucor miehei (MML) were found to be an efficient way in the synthesis of 2- alkylbenzimidazole. Compared with other substrates, methyl fatty acid esters with moderated chain length exhibited best activity with yield up to 95%. The mechanism of the domino process was clarified deeply through some detail experiments, including separation of intermediates. This efficient enzymatic domino process provides an attractive procedure for heterocyclic compound synthesis and could be regarded as a potential synthetic method in modern organic chemistry.

Fluorescent properties of 9-anthracenecarboxamides

A number of new 9-anthracenecarboxamides are synthesized in order to create new fluorescent probes for studying biological systems. The parameters of their fluorescence in organic solvents of various polarities are investigated, and possible mechanisms of

Pantothenic acid derivatives

Compounds represented by general formula (I) below STR1 wherein R1 and R2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group; R3 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5 ?C25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, or a group of formula STR2 where R4 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5 ?C25 -aliphatic hydrocarbon group which may be substituted with an aromatic group, and R5 represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrovarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula --X1 --A--Y1 --, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C2 ?C16 -aliphatic hydrocarbon group which may be substituted with an aromativ group, a divalent aromatic hydrocarbon group or a divalent aromatic heterocyclic group; one of X1 and Y1 represents STR3 and the other represents --O--, --S-- or STR4 in which R6 and R7 each represent a hydrogen atom or a lower alkyl group; (b) a group of formula --X2 --(CH2)l --Y2 --, where one of X2 and Y2 represents a group of formula STR5 and the other represents --O--, --S-- or STR6 in which STR7 represents a 4?7-membered, divalent nitrogen-containing aromatic heterocyclic group, and R6 has the same meaning as defined above, and l is 0, 1 or 2; or (c) a group of formula STR8 where m is 2 or 3; n is an integer of from 1 to 4. The compounds have excellent inhibitory activity against acyl Co A-cholesterol-acyltransferase.

Pantothenic acid derivatives

Compounds represented by general formula (I) below wherein R1 and R2, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group;, R3 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5～C25-aliphatic hydrocarbon group which may be substituted with an aro-matic group, or a group of formula where R4 represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5～C25--aliphatic hydrocarbon group which may be sub-stituted with an aromatic group, and, R5 represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrocarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula -X1-A-Y1-,where A represents a saturated or unsaturated, linear, branched or cyclic divalent C2～C16--aliphatic hydrocarbon group which may be sub-stituted with an aromatic group, a divalent aromatic hydrocarbon group or a divalent aro-matic heterocyclic group;, one of X1 and Y1 represents and the other represents -O-, -S- or in which R6 and R7 each represent a hydrogen atom or a lower alkyl group; (b) a group of formula -X2-(CH2)l-Y2-,where one of X2 and Y2 represents a group of formula and the other represents -O-, -S- or represents a 4～7--membered, divalent nitrogen-containing aromatic heterocyclic group, and R6 has the same meaning as defined above, and l is 0, 1 or 2; or (c) a group of formula where m is 2 or 3;, n is an integer of from 1 to 4. The compounds have excellent inhibitory activ-ity against acyl Co A-cholesterol-acyltransferase.