1353958-46-9

Basic information

• Product Name: 3-(3-nitrophenyl)-6-(4-(trifluoromethyl)phenyl)-1,2,4,5-tetrazine
• Synonyms: 3-(3-nitrophenyl)-6-(4-(trifluoromethyl)phenyl)-1,2,4,5-tetrazine
• CAS NO: 1353958-46-9
• Molecular Weight: 347.256
• Mol File: 1353958-46-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(3-nitrophenyl)-6-(4-(trifluoromethyl)phenyl)-1,2,4,5-tetrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-nitrophenyl)-6-(4-(trifluoromethyl)phenyl)-1,2,4,5-tetrazine(1353958-46-9)
• EPA Substance Registry System: 3-(3-nitrophenyl)-6-(4-(trifluoromethyl)phenyl)-1,2,4,5-tetrazine(1353958-46-9)

Safety Data

• Hazardous Substances Data: 1353958-46-9(Hazardous Substances Data)

Upstream product

• 618-94-0 3-nitrobenzoic acid hydrazide 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 1353958-44-7 N'-(chloro(4-(trifluoromethyl)phenyl)methylene)-3-nitrobenzohydrazonoyl chloride 
• 1203256-54-5 3-nitro-2-[(trifluoromethyl)benzoyl] hydrazide 

Downstream Products

• 1353958-47-0 3-(3-aminophenyl)-6-[4-(trifluoromethyl)phenyl]-s-tetrazine 
• 1353958-49-2 5-oxo-5-(3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenylamino)pentanoic acid 
• 1353958-50-5 tert-butyl (2-(5-oxo-5-((3-(6-[4-(trifluoromethyl)phenyl]-1,2,4,5-tetrazin-3-yl)phenyl)amino)pentanamido)ethyl)carbamate 
• 1356483-11-8 2,5-dioxopyrrolidin-1-yl 5-oxo-5-((6-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)pentanoate 

Relevant articles and documents

Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains

Fast and efficient: A library of trans-cyclooctene (TCO)-modified small molecules were immobilized on tetrazine-functionalized glass slides by using the fastest bioorthogonal reaction known. The resulting small-molecule microarray was screened against a variety of human bromodomains to identify protein-protein interaction inhibitors. Copyright

TETRAZINE-TRANS-CYCLOOCTENE LIGATION FOR THE RAPID CONSTRUCTION OF RADIONUCLIDE LABELED PROBES

A Diels-Alder adduct of a irans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.