1353958-47-0Relevant articles and documents
Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains
Zhang, Chong-Jing,Tan, Chelsea Y. J.,Ge, Jingyan,Na, Zhenkun,Chen, Grace Y. J.,Uttamchandani, Mahesh,Sun, Hongyan,Yao, Shao Q.
, p. 14060 - 14064 (2014/01/06)
Fast and efficient: A library of trans-cyclooctene (TCO)-modified small molecules were immobilized on tetrazine-functionalized glass slides by using the fastest bioorthogonal reaction known. The resulting small-molecule microarray was screened against a variety of human bromodomains to identify protein-protein interaction inhibitors. Copyright
TETRAZINE-TRANS-CYCLOOCTENE LIGATION FOR THE RAPID CONSTRUCTION OF RADIONUCLIDE LABELED PROBES
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, (2012/02/05)
A Diels-Alder adduct of a irans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.