1353985-76-8Relevant articles and documents
Synthesis of Imidazo[1,2-a]pyridines using fe3o 4@sio2 as an efficient Nanomagnetic catalyst via a one-pot Multicomponent reaction
Maleki, Ali
, p. 587 - 593 (2014)
A one-pot multicomponent synthesis of imidazo[1,2-a]pyridine derivatives by using pyridin-2-amines, aldehydes, and terminal alkynes in the presence of a catalytic amount of silica-supported iron oxide (Fe3O 4@SiO2) nanopar
Nonacidic Farnesoid X Receptor Modulators
Flesch, Daniel,Cheung, Sun-Yee,Schmidt, Jurema,Gabler, Matthias,Heitel, Pascal,Kramer, Jan,Kaiser, Astrid,Hartmann, Markus,Lindner, Mara,Lüddens-D?mgen, Kerstin,Heering, Jan,Lamers, Christina,Lüddens, Hartmut,Wurglics, Mario,Proschak, Ewgenij,Schubert-Zsilavecz, Manfred,Merk, Daniel
supporting information, p. 7199 - 7205 (2017/09/07)
As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of bile acid, lipid and glucose homeostasis, and liver protection. Clinical results have validated FXR as therapeutic target in hepatic and metabolic diseases. To date, potent FXR agonists share a negatively ionizable function that might compromise their pharmacokinetic distribution and behavior. Here we report the development and characterization of a high-affinity FXR modulator not comprising an acidic residue.
Mechanistic studies on a new catalyst system (CuI-NaHSO4· SiO2) leading to the one-pot synthesis of imidazo[1,2- a ]pyridines from reactions of 2-aminopyridines, aldehydes, and terminal alkynes
Mishra, Sarita,Ghosh, Rina
experimental part, p. 3463 - 3470 (2011/12/04)
One-pot reactions of aldehydes, 2-aminopyridines, and terminal alkynes, in the presence of the copper(I) iodide-NaHSO4·SiO2 combination catalyst in refluxing toluene, generate the corresponding imidazo[1,2-a]pyridines in high to excellent yields; the mechanism has been studied. Georg Thieme Verlag Stuttgart.