1354030-08-2

Upstream product

• 1354088-84-8 C₁₉H₁₉N₃O₂ 
• 1354030-07-1 3-(1H-imidazol-1-yl)-1-phenylpropyl 4-nitrobenzoate 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 34935-87-0 3-(1H-imidazole-1-yl)-1-phenylpropan-1-ol 
• 98-86-2 acetophenone 
• 28918-16-3 1-(1-imidazolyl)-3-phenyl-propan-3-one 

Relevant academic research and scientific papers

Synthesis and anti-candida potential of certain novel 1-[(3-substituted-3- phenyl)propyl]-1H-imidazoles

The synthesis and anti-Candida activity of 1-[(3-aroyloxy-3-phenyl)propyl]- 1H-imidazoles 5a-f and 1-[(3-alkyl/aralkyl/phenyl-3-phenyl)propan-3-ol]-1H- imidazoles 5g-j are reported. The influence of the ester formation and different substitutions on the anti-Candida activity of the alcohol 4 was investigated. Among the newly developed bioactive chemical entities, compounds 5b and 5c displayed minimum inhibitory concentrations (MICs) against Candida albicans and Candida pseudotropicales comparable to that of tioconazole and more potent than miconazole. The target compounds 1-[(3-aroyloxy-3-phenyl)propyl]-1H-imidazoles 5a-f were obtained in four steps starting from acetophenone 1 whereas 1-[(3-alkyl/aralkyl/phenyl-3-phenyl)propan-3-ol]-1H-imidazoles 5g-j were synthesized in three steps. Compounds 5b and 5c showed anti-Candida activity comparable to tioconazole and were more potent than miconazole. Copyright