1354041-90-9

Upstream product

• 623-43-8 methyl crotonate 
• 1354044-23-7 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide 
• 1354044-05-5 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide hydrochloride 
• 1446353-66-7 C₁₄H₉FN₄O 
• 1446353-53-2 C₁₄H₁₀FN₃O₃ 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 

Downstream Products

• 1446358-80-0 C₁₇H₁₀BrClFN₅O 
• 1446359-92-7 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-81-1 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-82-2 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-83-3 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-84-4 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-85-5 C₂₄H₁₇BrFN₅O₂ 
• 1446358-86-6 C₂₅H₁₉BrFN₅O₃ 
• 1446358-87-7 C₂₉H₂₂FN₅O₃S 
• 1446358-88-8 C₂₁H₁₄FN₅O₂S 
• 1446358-90-2 C₂₂H₁₅FN₆O₂ 
• 1446358-89-9 C₃₀H₂₃FN₆O₃ 
• 1446358-91-3 C₂₈H₂₁FN₆O₃S 
• 1446358-92-4 C₂₀H₁₃FN₆O₂S 

Relevant academic research and scientific papers

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

In recent years, soluble guanylate cyclase (sGC, EC 4.6.1.2) has emerged as an attractive therapeutic target for treating cardiovascular diseases and diseases associated with fibrosis and end-organ failure. Herein, we describe our design and synthesis of

2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS

2-Benzyl, 3 - (pyrimidin- 2 -YL) substituted pyrazoles are described. They are useful as stimulators of sGC, particularly NO - independent, heme - dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

SGC STIMULATORS

Compounds of Formula (I) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.