135426-95-8Relevant articles and documents
Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 2. Synthesis and Biological Activites of a Series of Substituted Pyrydynes Containing a Hydroxyphosphinyl Moiety
Robl, Jeffrey A.,Duncan, Laurelee A.,Pluscec, Jelka,Karanevsky, Donald S.,Gordon, Eric M.,et al.
, p. 2804 - 2815 (2007/10/02)
A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionality have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase.Systematic substitution of both R1-R4 and X-Y