135440-52-7

Basic information

• Product Name: 5-exo-(2'-diphenylphosphinoyl-1'-oxoethyl)-6-exo-hydroxymethyl-7-oxabicyclo<2.2.1>hept-2-ene hemiacetal
• CAS NO: 135440-52-7
• Molecular Weight: 368.369
• Mol File: 135440-52-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-exo-(2'-diphenylphosphinoyl-1'-oxoethyl)-6-exo-hydroxymethyl-7-oxabicyclo<2.2.1>hept-2-ene hemiacetal(CAS DataBase Reference)
• NIST Chemistry Reference: 5-exo-(2'-diphenylphosphinoyl-1'-oxoethyl)-6-exo-hydroxymethyl-7-oxabicyclo<2.2.1>hept-2-ene hemiacetal(135440-52-7)
• EPA Substance Registry System: 5-exo-(2'-diphenylphosphinoyl-1'-oxoethyl)-6-exo-hydroxymethyl-7-oxabicyclo<2.2.1>hept-2-ene hemiacetal(135440-52-7)

Safety Data

• Hazardous Substances Data: 135440-52-7(Hazardous Substances Data)

Upstream product

• 51112-82-4 (1R,2S,6S,7S)-4,10-Dioxa-tricyclo[5.2.1.0^2,6]dec-8-en-3-one 
• 2129-89-7 diphenyl(methyl)phosphine oxide 

Downstream Products

• 135440-55-0 6-exo-(3,5-dinitrobenzoyloxymethyl)-5-exo-vinyl-7-oxabicyclo<2.2.1>hept-2-ene 
• 87832-30-2 (Z)-1-(3,5-Dinitrobenzoyloxy)penta-2,4-diene 
• 135440-53-8 2-(Diphenyl-phosphinoyl)-1-((1R,2R,3S,4S)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl)-ethanol 
• 135440-56-1 (Z)-5-Diphenylphosphinoyl-4-hydroxypent-2-en-1-ol 
• 135440-57-2 (furan-2-ylmethyl)diphenylphosphine oxide 

Relevant articles and documents

The Synthesis of (Z)-Penta-2,4-dien-1-ol and Substituted (E)-Pentadienols by the Stereochemically Controlled Horner-Wittig Reaction

Acylation of Ph2P(O)Me with a lactone gives a Horner-Wittig intermediate with a Z-double bond protected as a Diels-Alder adduct with furan and hence (Z)-penta-2,4-dien-1-ol.Substituted (E)-penta-2,4-dien-1-ols are available by a more general route involving addition of enals to phosphine oxides, a regiochemically controlled allylic alcohol transposition, and a Horner-Wittig reaction.The geometry of only one double bond can be controlled.