1354413-99-2Relevant academic research and scientific papers
Versatile synthesis of 5-aminoimidazole-4-carboxylic acid derivatives
Dias, Alice M.,Vila-Ch?, A. Sofia,Costa, A. Luísa,Cunha, Daniela P.,Senhor?es, Nádia,Proen?a, M. Fernanda
experimental part, p. 2675 - 2680 (2011/12/04)
5-Amino imidazole 4-substituted carboxamidines and 4-substituted imidoyl cyanides were selectively obtained under mild experimental conditions from reaction of the easily accessible 5-amino-4-cyanoformimidoyl imidazoles with primary aliphatic and aromatic amines, ammonia, and amino acids in a one-pot reaction. When alcohols were used, the corresponding 5-aminoimidazole 4-carboximidates were isolated. An equally simple reaction occurred when the starting imidazoles were combined with water to give 5-aminoimidazole 4-acyl cyanides. Georg Thieme Verlag Stuttgart · New York.
