1354438-27-9Relevant academic research and scientific papers
Synthesis and biological evaluation of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors
Kim, Se Hoan,Bok, Ju Han,Lee, Jae Hong,Kim, Il Hyang,Kwon, Sung Wook,Lee, Gui Bin,Kang, Seung Kyu,Park, Ji Seon,Jung, Won Hoon,Kim, Hee Yeon,Rhee, Sang Dal,Ahn, Sung Hoon,Bae, Myung Ae,Ha, Deok Chan,Kim, Ki Young,Ahn, Jin Hee
, p. 88 - 93 (2012/05/04)
A new series of cyclic sulfamide derivatives were synthesized and evaluated for their ability to inhibit 11β-HSD1. Among this series, 18e showed good in vitro activity toward human 11β-HSD1, selectivity against 11β-HSD2, microsomal stability, and pharmacokinetic and safety profiles (hERG, CYP, and acute toxicity). Additionally, 18e exhibited good in vivo efficacy in rat and monkey models.
