1354448-68-2 Usage
Description
[1-(3-Chloro-5-trifluoroMethyl-pyridin-2-yl)-pyrrolidin-3-yl]-carbaMic acid tert-butyl ester is a pyrrolidine derivative featuring a tert-butyl ester functional group, along with a chloro and trifluoromethyl-substituted pyridine ring and a pyrrolidine ring. This chemical compound is recognized for its potential applications in the synthesis of pharmaceuticals and agrochemicals, serving as an intermediate or building block due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
[1-(3-Chloro-5-trifluoroMethyl-pyridin-2-yl)-pyrrolidin-3-yl]-carbaMic acid tert-butyl ester is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structure allows for the creation of molecules with specific therapeutic properties, contributing to the advancement of drug discovery and design.
Used in Agrochemical Industry:
In the agrochemical sector, [1-(3-Chloro-5-trifluoroMethyl-pyridin-2-yl)-pyrrolidin-3-yl]-carbaMic acid tert-butyl ester is utilized as a building block in the synthesis of agrochemicals. Its incorporation into these products can enhance their effectiveness in pest control and crop protection, thereby supporting agricultural productivity and sustainability.
Note: The specific applications and reasons for the use of [1-(3-Chloro-5-trifluoroMethyl-pyridin-2-yl)-pyrrolidin-3-yl]-carbaMic acid tert-butyl ester in the pharmaceutical and agrochemical industries are subject to ongoing research and development, as its full potential and properties are yet to be fully explored and understood.
Check Digit Verification of cas no
The CAS Registry Mumber 1354448-68-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,4,4,4 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1354448-68:
(9*1)+(8*3)+(7*5)+(6*4)+(5*4)+(4*4)+(3*8)+(2*6)+(1*8)=172
172 % 10 = 2
So 1354448-68-2 is a valid CAS Registry Number.
1354448-68-2Relevant articles and documents
Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12)
Ogasawara, Daisuke,Ichu, Taka-Aki,Jing, Hui,Hulce, Jonathan J.,Reed, Alex,Ulanovskaya, Olesya A.,Cravatt, Benjamin F.
, p. 1643 - 1656 (2019)
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lysophosphatidylserine (lyso-PS) and lysophosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/PI pathway in regulating (neuro)immunological functions in both the central nervous system and periphery. Selective inhibitors of ABHD12 would offer valuable pharmacological probes to complement genetic models of ABHD12-regulated (lyso)-PS/PI metabolism and signaling. Here, we provide a detailed description of the discovery and activity-based protein profiling (ABPP) guided optimization of reversible thiourea inhibitors of ABHD12 that culminated in the identification of DO264 as a potent, selective, and in vivo active ABHD12 inhibitor. We also show that DO264, but not a structurally related inactive control probe (S)-DO271, augments inflammatory cytokine production from human THP-1 macrophage cells. The in vitro and in vivo properties of DO264 designate this compound as a suitable chemical probe for studying the biological functions of ABHD12-(lyso)-PS/PI pathways.
