1354577-57-3Relevant academic research and scientific papers
Highly enantioselective total synthesis of (+)-isonitramine
Park, Yohan,Lee, Young Ju,Hong, Suckchang,Lee, Myungmo,Park, Hyeung-Geun
, p. 852 - 854 (2012)
A new efficient enantioselective synthetic method of (+)-isonitramine is reported. (+)-Isonitramine was obtained in 12 steps (98% ee and 43% overall yield) from δ-valerolactam via enantioselective phase-transfer catalytic alkylation, Dieckman condensation
Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents
Lee, Hwanhyuk,Hwang, Su Jung,Jung, Jisung,Hong, Suckchang,Lee, Myungmo,Park, Hyeung-Geun,Lee, Hyo-Jong,Park, Yohan
, p. 1264 - 1270 (2014)
Asymmetric synthesis of α-quaternary chiral lactam derivatives as novel anticancer agents and evaluation of their cytotoxic potentials and spectrums are reported. Among the developed lactam derivatives, the most active new compounds (S)-4m and (S)-4n synthesized via asymmetric phase-transfer catalytic alkylation in very high optical yields (98 % ee) show promising in vitro anticancer activities with low micromolar IC50 values against colon, uterus, lung, and breast human cancer cells.
Enantioselective Total Synthesis of Nitraria Alkaloids: (+)-Nitramine, (+)-Isonitramine, (-)-Isonitramine, and (-)-Sibirine via Asymmetric Phase-Transfer Catalytic α-Allylations of α-Carboxylactams
Yang, Jewon,Park, Yohan,Yang, Sehun,Lee, Geumwoo,Ha, Min Woo,Kim, Mi-Hyun,Hong, Suckchang,Park, Hyeung-Geun
, p. 4375 - 4390 (2021/02/05)
Many optically active 2-azaspirocyclic structures have frequently been found in biologically active natural products. In particular, Nitraria alkaloids, (+)-nitramine, (+)-isonitramine, (-)-isonitramine, and (-)-sibirine, have stereogenicity on their quat
α-alkyl-α-carbonyl lactam derivatives and their stereoisomers, and pharmaceutical composition containing the same
-
, (2016/12/01)
Disclosed are andalpha;-alkyl-andalpha;-carbonyl lactam derivatives having novel anticancer activity, a stereomer thereof, and a pharmaceutical composition containing the same. The composition including compounds of the present invention is effective in p
Highly enantioselective phase-transfer catalytic α-alkylation of α-tert-butoxycarbonyllactams: Construction of β-quaternary chiral pyrrolidine and piperidine systems
Park, Yohan,Lee, Young Ju,Hong, Suckchang,Kim, Mi-Hyun,Lee, Myungmo,Kim, Taek-Soo,Lee, Jae Kyun,Jew, Sang-Sup,Park, Hyeung-Geun
, p. 3313 - 3318 (2012/01/19)
A new enantioselective α-alkylation of α-tert- butoxycarbonyllactams for the construction of β-quaternary chiral pyrrolidine and piperidine core systems is reported. α-Alkylations of N-methyl-α-tert-butoxycarbonylbutyrolactam and N-diphenylmethyl-α- tert-
