1354640-70-2Relevant academic research and scientific papers
Palladium-catalyzed intramolecular hydroarylation of 2-bromobenzyl propargyl ethers: A new access to exocyclic isochromans
Nandakumar, Avanashiappan,Balakrishnan, Krishnamoorthy,Perumal, Paramasivan Thirumalai
, p. 2733 - 2739 (2011/12/04)
An efficient, stereo- and regioselective palladium-catalyzed 6-exo-dig intramolecular hydroarylation of propargyl ethers which provides a concise access to functionalized isochromans in high yields has been developed. A wide range of substrates possessing aromatic, aliphatic and heteroaromatic alkynes can be efficiently transformed into the targeted isochromans. Irrespective of the nature of the substrates, the cyclization follows highly selective -stereo- and regiochemistry.
