135467-69-5Relevant articles and documents
A Catalyst-Controlled Aerobic Coupling of ortho-Quinones and Phenols Applied to the Synthesis of Aryl Ethers
Huang, Zheng,Lumb, Jean-Philip
, p. 11543 - 11547 (2016)
ortho-Quinones are underutilized six-carbon-atom building blocks. We herein describe an approach for controlling their reactivity with copper that gives rise to a catalytic aerobic cross-coupling with phenols. The resulting aryl ethers are generated in high yield across a broad substrate scope under mild conditions. This method represents a unique example where the covalent modification of an ortho-quinone is catalyzed by a transition metal, creating new opportunities for their utilization in synthesis.
Synthesis and anti-inflammatory evaluations of β-lapachone derivatives
Tseng, Chih-Hua,Cheng, Chih-Mei,Tzeng, Cherng-Chyi,Peng, Shin-I,Yang, Chiao-Li,Chen, Yeh-Long
, p. 523 - 531 (2013/02/25)
β-Lapachone (β-LAPA), a natural product from the lapacho tree in South America, is a potential chemotherapeutic agent that exhibit a wide variety of pharmacological effects such as anti-virus, anti-parasitic, anti-cancer, and anti-inflammatory activities.