135468-89-2Relevant academic research and scientific papers
A Novel Entry into Cyclopropanated Sugar Amino Acids
Zaman, Fakhar-uz,Fatima, Ayjaz,Malik, Abdul,Voelter, Wolfgang
, p. 1434 - 1438 (2007/10/02)
Reaction of sugar triflates (1) and (2) with tert-butyl cyanoacetate in presence of sodium hydride affords the cyclopropanated sugars (3) and (4), followed by selective hydrolysis of the ester group to free acids (5) and (6), respectively.Couplings of (5)
Solid Phase Synthesis of Muramyl Dipeptide Derivatives and Investigations on their Biological Activities
Tschakert, Jochen,Voelter, Wolfgang
, p. 702 - 716 (2007/10/02)
New muramyl dipeptide derivatives with exchanged carbohydrate residues are described.Each derivative is synthesized via a solid phase synthesis using an aminomethyl anchor resin.All synthetic products can be isolated in good yields.Their biological activities are tested by the luminol-dependent chemiluminescence associated with the phagocytosis of opsonized zymosan by granulocytes. - Keywords: Muramyl Dipeptide, Solid Phase Synthesis, Chemiluminescence, Glycopeptide Derivatives
Synthesis of Disubstituted Cyclopropapyranosides from 2,3-Epoxy-4-triflate-pyranosides
Zaman, Fakhar,Fatima, Ayjaz,Voelter, Wolfgang
, p. 1101 - 1104 (2007/10/02)
Reaction of benzyl 2,3-anhydro-4-O-trifluoromethylsulfonyl-β-L-ribopyranoside (1) and benzyl 2,3-anhydro-4-O-trifluoromethylsulfonyl-α-D-ribopyranoside (4) with malonic acid derivatives yields, via the carbanions, the cyclopropa-monosaccharides 3 and 6.The ester residues attached to the cyclopropane moiety can be saponified to give the corresponding acids which can be coupled to new carbohydrate amino acid derivatives of type 9 which are of biological interest in different immunological assays. Key Words: Carbohydrates / Cyclopropapyranosides / Sugar triflates
