135468-89-2Relevant articles and documents
Solid Phase Synthesis of Muramyl Dipeptide Derivatives and Investigations on their Biological Activities
Tschakert, Jochen,Voelter, Wolfgang
, p. 702 - 716 (2007/10/02)
New muramyl dipeptide derivatives with exchanged carbohydrate residues are described.Each derivative is synthesized via a solid phase synthesis using an aminomethyl anchor resin.All synthetic products can be isolated in good yields.Their biological activities are tested by the luminol-dependent chemiluminescence associated with the phagocytosis of opsonized zymosan by granulocytes. - Keywords: Muramyl Dipeptide, Solid Phase Synthesis, Chemiluminescence, Glycopeptide Derivatives
Synthesis of Disubstituted Cyclopropapyranosides from 2,3-Epoxy-4-triflate-pyranosides
Zaman, Fakhar,Fatima, Ayjaz,Voelter, Wolfgang
, p. 1101 - 1104 (2007/10/02)
Reaction of benzyl 2,3-anhydro-4-O-trifluoromethylsulfonyl-β-L-ribopyranoside (1) and benzyl 2,3-anhydro-4-O-trifluoromethylsulfonyl-α-D-ribopyranoside (4) with malonic acid derivatives yields, via the carbanions, the cyclopropa-monosaccharides 3 and 6.The ester residues attached to the cyclopropane moiety can be saponified to give the corresponding acids which can be coupled to new carbohydrate amino acid derivatives of type 9 which are of biological interest in different immunological assays. Key Words: Carbohydrates / Cyclopropapyranosides / Sugar triflates