18403-22-0

Basic information

• Product Name: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol
• Synonyms: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol
• CAS NO: 18403-22-0
• Molecular Weight: 280.321
• Mol File: 18403-22-0.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol(18403-22-0)
• EPA Substance Registry System: (3aS,6S,7R,7aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-ol(18403-22-0)

Safety Data

• Hazardous Substances Data: 18403-22-0(Hazardous Substances Data)

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 77-76-9 2,2-dimethoxy-propane 
• 7473-38-3 benzyl β-L-arabinopyranoside 
• 100-51-6 benzyl alcohol 
• 7296-56-2 β-L-arabinopyranose 
• 5328-37-0 L-arabinose 
• 7296-55-1 L-arabinose 
• 87-72-9 L-(+)-arabinose 
• 116-11-0 2-Methoxypropene 
• 67-64-1 acetone 

Downstream Products

• 18402-79-4 Benzyl 2-O-benzoyl-β-L-arabinopyranoside 
• 550346-08-2 benzyl 2-O-benzoyl-3,4-O-benzylidene-β-L-arabinopyranoside 
• 550346-09-3 C₂₆H₂₄O₇ 
• 22900-10-3 (4R,5S)-tetrahydro-2H-pyran-2,4,5-triol 
• 136737-25-2 benzyl 2-deoxy-3,4-O-isopropylidene-β-L-erythro-pentopyranoside 
• 432492-86-9 N-(6-benzyloxy-2,2-dimethyldihydro-[1,3]dioxolo[4,5-c]pyran-7-ylidene)-N'-(4-toluenesulfonyl)hydrazine 
• 171866-28-7 1-O-methyl-2,3,5-tri-O-benzoyl-L-ribofuranose 
• 3080-30-6 1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose 
• 87-72-9 L-ribose 
• 171866-29-8 1-bromo-2-deoxy-2-β-fluoro-3,5-di-O-benzoyl-α-L-arabinose 
• 171866-30-1 1,3,5-Tri-O-benzoyl-α-L-ribofuranose 
• 171721-00-9 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-L-arabinofuranose 
• 171720-99-3 1,3,5-tri-O-benzoyl-2-O-(2-imidazolylsulfonyl)-α-L-ribofuranose 
• 163252-36-6 clevudine 

Relevant articles and documents

Hafnium Triflate as a Highly Potent Catalyst for Regio- and Chemoselective Deprotection of Silyl Ethers

As a Group IVB transition metal Lewis acid, hafnium triflate [Hf(OTf) 4 ] exhibited exceptionally high potency in desilylations. Since the amounts of Hf(OTf) 4 required for the deprotection of 1°, 2°, 3° alkyl and aryl tert -butyldimethylsilyl (TBS) ethers are significantly different, ranging from 0.05 mol% to 3 mol%, regioselective deprotection of TBS could be easily implemented. Moreover, chemoselective cleavage of different silyl ethers or removal of TBS in the presence of most hydroxyl protecting groups was also accomplished. NMR analyses of silyl products from TBS deprotection indicated that Hf(OTf) 4 -catalyzed desilylation may proceed via different mechanisms, depending on the solvent used.

BIARYL AMIDES WITH MODIFIED SUGAR GROUPS FOR TREATMENT OF DISEASES ASSOCIATED WITH HEAT SHOCK PROTEIN PATHWAY

Provided are biaryl amides and coumarin-based compounds with modified sugar groups for treatment of diseases associated with heat shock protein pathway. The compounds having the following formulas, wherein variables are as defined herein. Formulae (I), (II), (III), (IV), and (V), Pharmaceutical compositions of the compounds are also provided. These biaryl amides and coumarin-based derivatives with modified sugar groups are useful for treatment and prevention of diseases and disorders, including neurological disorders, such as neurodegenerative diseases and nerve damaging disorders, for example, diabetic peripheral neuropathy.

Regioselective ring opening of exo- and endo-3,4-benzylidene acetals of arabinopyranoside derivatives with Lewis acids and reducing agents

Dioxolane type 3,4-benzylidene acetals of benzyl β-l-arabinose either as a mixture or pure exo- and endo-isomers cleavaged with BF3· OEt2/Et3SiH in dichloromethane or acetonitrile regioselectively, provided the 4-O-benzyl-