135473-20-0Relevant articles and documents
The 'β-fluorine effect' in the non-metal hydride radical deoxygenation of fluorine-containing nucleoside xanthates
Siddiqui, Maqbool A.,Driscoll, John S.,Abushanab, Elie,Kelley, James A.,Barchi Jr., Joseph J.,Marquez, Victor E.
, p. 1 - 12 (2000)
An alternative method to conduct a Barton-McCombie deoxygenation in nucleosides is described. The utility of the procedure is limited to structures with an electronegative substituent, particularly fluorine, in the β-position relative to the radical cente
2'-fluorofuranosyl derivatives and novel method of preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
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, (2008/06/13)
A compound has the formula STR1 wherein R is selected from the group consisting of (C7 -C20)aroyl, (C6 -C20)aryl, aralkyl and alkylaryl, and (C1 -C10)alkyl-di(C6 -C20)aryl Si, R' is selected from the group consisting of (C1 -C10)alkyl, (C7 -C20)aroyl and (C2 -C12)acyl, all of which may be further substituted with O, S, N or alkyl, and R'" is selected from the group consisting of halogen, (C1 -C10)alkoxy, (C1 -C10)acyloxy, O-methane-sulfonyl and O-p-toluenesulfonyl. A composition of matter comprises 0.001 to 99.999 wt % of the above compound.
A more expedient approach to the synthesis of anti-HIV-active 2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl nucleosides
Wysocki Jr.,Siddiqui,Barchi Jr.,Driscoll,Marquez
, p. 1005 - 1008 (2007/10/02)
Starting with 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose, a versatile method for the synthesis of 2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl nucleosides is described and illustrated with the synthesis of 9-(2,3-dideoxy-2-fluoro-β-D-threop
