1354832-41-9

Upstream product

• 1354832-39-5 9,N₂,N₂,N₆,N₆-penta(Boc)-2,6-diaminopurine 
• 1354832-40-8 N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diamino-9H-purine 
• 5437-45-6 Benzyl bromoacetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1904-98-9 2,6-diaminopurine 

Downstream Products

• 1354832-42-0 N₂,N₂,N₆,N₆-tetra(Boc)-2,6-diaminopurin-9-ylacetic acid 

Relevant academic research and scientific papers

Synthesis and oligomerization of Fmoc/Boc-protected PNA monomers of 2,6-diaminopurine, 2-aminopurine and thymine

A Boc-protecting group strategy for Fmoc-based PNA (peptide nucleic acid) oligomerization has been developed for thymine, 2,6-diaminopurine (DAP) and 2-aminopurine (2AP). The monomers may be used interchangeably with standard Fmoc PNA monomers. The DAP monomer was incorporated into a PNA and was found to selectively bind to T (ΔTm ≥ +6 °C) in a complementary DNA strand. The 2AP monomer showed excellent discrimination of T (ΔT m ≥ +12 °C) over the other nucleobases. 2AP also acted as a fluorescent probe of the PNA:DNA duplexes and displayed fluorescence quenching dependent on the opposite base.