135501-21-2

Upstream product

• 135393-99-6 (2S)-2-((2S,4S,5S,6R)-6-<(1S,2S)-2-(tert-Butyldimethylsilyloxy)-1-methylbutyl>-2-(p-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propanal 
• 135393-87-2 (2R,4R,5R,6R)-4-<(1S,2S)-2-(tert-Butyldimethylsiloxy)-1-methylbutyl>-6-<(1R,2Z)-3-methoxy-1-methyl-2-propenyl>-2-(p-methoxyphenyl)-5-methyl-1,3-dioxane 
• 116706-51-5 (1Z,3R,4R,5R,6R,7S,8S)-8-(tert-Butyldimethylsiloxy)-1-methoxy-6-(p-methoxybenzyloxy)-3,5,7-trimethyl-1-decen-4-ol 
• 61090-97-9 4,6-dimethyl-6(E)-nonen-3-one 
• 116706-50-4 (2S,3S,4S,5S)-5-(tert-Butyldimethylsilyloxy)-3-(p-methoxybenzyloxy)-2,4-dimethylheptanal 

Relevant academic research and scientific papers

Stereoselective Synthesis of Alcohols, XXXVIII. - Stereoselective Total Synthesis of the Denticulatins

The total synthesis of the denticulatins 1 is described.Key feature is the efficient generation of the C-1-to-C-9 building block 37 by three consecutive stereoselective carbon-carbon bond-forming steps using chiral allylboronates.The C10-to-C-17 building block was obtained by kinetic Sharpless resolution of an allylic alcohol followed by an Ireland-Claisen rearrangement. Key Words: Marine natural products / Hemiketal formation, selective / Denticulatins