1355083-83-8Relevant academic research and scientific papers
The behaviour of Bis(diphenylphosphino)alkanes towards different active centres
Ewies, Ewies F.,El-Sayed, Naglaa F.,Boulos, Leila S.
, p. 417 - 421 (2016)
Benzophenones (diarylmethanones) are important starting materials in the synthesis and preparation of organic compounds such as heat-resistant resins, various drugs, and natural products.1-7 1,1′-(Azodicarbonyl)dipiperidine has different pharmacological and biological activities.8-13 The versatility of isatin (1H-indole-2,3-dione) in synthetic organic chemistry is shown in its biological and pharmacological properties and its extensive use in organic synthesis.14 Moreover, quinoxaline 1,4-di-N-oxide is a building block that has a broad range of biological applications.15 Bis(diphenylphosphino)alkanes have been reported as anticancer agents.16-20The useful applications of these starting materials, coupled with our interest in organophosphorus chemistry,21-25 encouraged us to synthesise new organophosphorus compounds and to identify the preferred site of attack of these compounds. We sought to obtain the target compounds by reacting bis(diphenylphosphino) alkanes 1a-c with some different organic compounds; namely, benzophenone2, 1,1′-(azodicarbonyl)dipiperidine (ADDP, 3), isatin 4a and 4b, and quinoxaline 1,4-di-N-oxide 5 (Scheme 1).
Reactions of 1,1′-(azodicarbonyl)dipiperidine with organophosphorus reagents
Boulos, Leila S.,Abdel-Malek, Hoda A.,El-Sayed, Naglaa F.,Moharam, Maysa E.
experimental part, p. 225 - 237 (2012/03/26)
1,1′carbonyl)dipiperidine reacts with tris(dimethylamino)phosphine, trialkyl phosphites, phosphorus ylides, and Lawesson's reagents to give the phosphorodihydrazidic amide, oxadiazole, dihydropyridazine, ethylenic, and thicarbonyl products, respectively. The antibacterial and antifungal activities for the new compounds are reported. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: Biological Evaluation.
