135513-32-5Relevant articles and documents
Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: New reductive alkylating DNA cleaving agents
Islam,Skibo,Dorr,Alberts
, p. 2954 - 2961 (2007/10/02)
Described herein are structure-activity studies of new antitumor agents based on the pyrrolo[1,2-a]benzimidazole (PBI) ring system. These compounds were designed as new DNA cross-linkers mimicking the mitomycin antitumor agents. Actually, the PBI derivati
Synthesis and elucidation of azamitosene and iminoazamitosene
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, (2008/06/13)
The synthesis of 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole-5,8-diones (azamitosenes was carried out in conjunction with the design of potential DNA crosslinkers activated by reduction (reductive alkylation). These quinones resemble mitosene antitumor age