59007-79-3

Usage

Heterocyclic chemical compound

A compound that contains a ring of atoms with at least one atom being different from carbon, in this case, the fused benzimidazole and pyrrole ring system.

Fused benzimidazole and pyrrole ring system

The compound has two ring structures that are connected together, specifically a benzimidazole ring and a pyrrole ring.

Derivative of benzimidazole

The compound is a modified version of the benzimidazole molecule, which is a heterocyclic aromatic organic compound.

Biological activity

The compound has the ability to interact with biological systems, making it of interest for pharmaceutical research.

Potential as an antifungal and antibacterial agent

The compound has been investigated for its ability to inhibit the growth of fungi and bacteria, which could make it useful in the development of new treatments for infections.

Use in the treatment of neurological disorders

The compound has been studied for its potential to be used in the treatment of neurological disorders, although the specific disorders it may be useful for are not mentioned in the material provided.

Subject of continued study and interest in the field of medicinal chemistry

The unique structure and potential applications of the compound make it an important area of research for the development of new drugs and therapies.

Upstream product

• 135513-32-5 4-acetamido-5-(1-pyrrolidino)toluene 
• 54856-03-0 methyl-[3-(5-methyl-1⁽³⁾H-benzoimidazol-2-yl)-propyl]-amine 
• 616-45-5 2-pyrrolidinon 
• 38939-88-7 2-chloro-4-methyl-1-nitrobenzene 
• 221548-37-4 2-cyclopropyl-5-methyl-1H-benzimidazole 
• 96-48-0 4-butanolide 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 640768-21-4 4-Methyl-2-pyrrolidin-1-yl-phenylamine 
• 123567-04-4 3-(N-pyrrolidino)-4-nitrotoluene 

Downstream Products

• 135513-35-8 5-amino-7-methyl-2,3-dihydro-1H-pyrrolo<1,2-a>benzimidazole 

Relevant academic research and scientific papers

BENZIMIDAZOLE COMPOUND AND SYNTHESIS METHOD THEREOF

PROBLEM TO BE SOLVED: To provide a novel benzimidazole compound having tetracyclic condensed ring and a synthesis method thereof. SOLUTION: A benzimidazole compound is represented by the formula (I). A method for synthesizing the benzimidazole compound represented by the formula (I) includes the step of reacting ortho-phenylene diamine and a lactone compound and further reacting the resulting benzimidazole compound with the lactone compound. In the formula, R1 and R4 are each independently H, a methyl group or an ethyl group excluding that two of R4 are ethyl groups or methyl groups at same time, R2 and R3 are each independently H or a methyl group, m and n are integers of 1 to 2 and n is 1 when m is 2. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Synthesis of condensed heterocycles via cyclopropylimine rearrangement of cyclopropylazoles

Thermal cyclopropylimine rearrangement of cyclopropylazoles into condensed heterocycles and factors affecting the regioselectivity and conversion are reported. A method of conducting the reaction in the absence of solvents is developed. A series of 2-cyclopropylazoles, including novel examples, is synthesized and their transformations into the corresponding condensed heterocyclic compounds (2,3-dihydro-1H-pyrroles and 6,7-dihydro-5H-pyrrolo[2,1- b]thiazolium salts) are studied.

A REGIOSELECTIVE METAL CATALYZED SYNTHESIS OF ANNELATED BENZIMIDAZOLES AND AZABENZIMIDAZOLES

A regioselective metal catalyzed synthesis of benzimidazoles and azabenzimidazoles The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N- substituted benzimidazoles or azabenzimidazoles of formula (I) starting from 2-halo- nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: New reductive alkylating DNA cleaving agents

Described herein are structure-activity studies of new antitumor agents based on the pyrrolo[1,2-a]benzimidazole (PBI) ring system. These compounds were designed as new DNA cross-linkers mimicking the mitomycin antitumor agents. Actually, the PBI derivati

Process for preparing 1,2-fused-1,3-dinitrogen-heterocyclic compounds

1,2-FUSED FIVE-MEMBERED OR SIX-MEMBERED 1,3-DINITROGEN-HETEROCYCLIC COMPOUNDS, USFUL AS ANTI-CORROSION AGENTS, HAVING THE FORMULA STR1 wherein A is an optionally substituted, optionally polynuclear orth- or peri-arylene radical and B is an optionally substituted alkylene chain STR2 WHEREIN R1 and R2 individually represent hydrogen and/or optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radicals and n represents a number from 3 to 6, Or B is an optionally substituted 1,8-naphthylene, 2,2'-diphenylene or 4,5-phenanthrylene radical, Are prepared by splitting a five-membered or six-membered 1,3- dinitrogen-heterocyclic compound, which contains a 2-(ω-amino group) side chain, having the formula STR3 wherein A and B have the meanings indicated above and R3 and R4 are hydrogen, lower alkyl, cycloalkyl or aralkyl but at least one of the two radicals R3 and R4 must represent hydrogen.