1355150-03-6Relevant articles and documents
Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide
Halby, Ludovic,Champion, Christine,Senamaud-Beaufort, Catherine,Ajjan, Sophie,Drujon, Thierry,Rajavelu, Arumugam,Ceccaldi, Alexandre,Jurkowska, Renata,Lequin, Olivier,Nelson, William G.,Guy, Alain,Jeltsch, Albert,Guianvarc'h, Dominique,Ferroud, Clotilde,Arimondo, Paola B.
, p. 157 - 165 (2012)
DNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic modification involved in gene regulation. Families of conjugates of procainamide, an inhibitor of DNMT1, were conceived and produced by rapid synthetic pathways. Six compoun