1355150-09-2Relevant academic research and scientific papers
SUBSTITUTED AMINO - BENZOIC ACID DERIVATIVES AS INHIBITORS OF DNA METHYLTRANSFERASES
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, (2012/04/10)
The present invention relates to a compound having the following formula (I), wherein : - R1 and R2 are alkyl groups having from 1 to 12 carbon atoms; - X1 is NH or O;- R3, R4, R5 and Rsub
Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide
Halby, Ludovic,Champion, Christine,Senamaud-Beaufort, Catherine,Ajjan, Sophie,Drujon, Thierry,Rajavelu, Arumugam,Ceccaldi, Alexandre,Jurkowska, Renata,Lequin, Olivier,Nelson, William G.,Guy, Alain,Jeltsch, Albert,Guianvarc'h, Dominique,Ferroud, Clotilde,Arimondo, Paola B.
, p. 157 - 165 (2012/04/17)
DNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic modification involved in gene regulation. Families of conjugates of procainamide, an inhibitor of DNMT1, were conceived and produced by rapid synthetic pathways. Six compoun
