1355340-84-9

Upstream product

• 161867-43-2 (2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsilanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-2-carbaldehyde 
• 1355340-63-4 C₃₁H₄₅N₃O₇Si₂ 
• 1355340-62-3 C₂₃H₄₀N₂O₈Si₂ 
• 1355340-61-2 C₂₃H₄₂N₂O₇Si₂ 

Downstream Products

• 1355340-88-3 C₃₃H₅₁N₃O₁₀Si₂ 

Relevant academic research and scientific papers

Exploring the chemistry of epoxy amides for the synthesis of the 2′′-epi -diazepanone core of liposidomycins and caprazamycins

New synthetic strategies have been explored for the synthesis of the structural core of liposidomycins and caprazamycins, an intriguing class of complex nucleoside-type antibiotics. This structural core is comprised of a cyclic diazepanone system linked to an uridyl fragment. The various synthetic approaches have in common that they originate from an epoxy amide derived from uridine, obtained via reaction of uridyl aldehyde 19 with an amide-stabilized sulfur ylide. Two different strategies were shown to be efficient in constructing the diazepanone ring system: (a) a reductive amination of an epoxy aldehyde with N-methylamine with subsequent intramolecular oxirane ring opening and (b) a carbene insertion reaction of an acyclic diazoamine precursor.