1355361-83-9

Upstream product

• 68867-14-1 2-methyl-5-benzothiazolol 
• 1355361-81-7 5-(cyclohexyloxy)-2-methyl-1,3-benzothiazole 
• 105-58-8 Diethyl carbonate 
• 108-93-0 cyclohexanol 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 1355361-90-8 ethyl 2-cyclohexyl-8-(cyclohexyloxy)-1-oxo-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylate 
• 1355361-95-3 ethyl 2-acetyl-8-(cyclohexyloxy)-1-oxo-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylate 
• 1355361-96-4 ethyl 8-(cyclohexyloxy)-1-oxo-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylate 
• 1355361-72-6 8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylic acid 
• 1355361-71-5 2-cyclohexyl-8-(cyclohexyloxy)-1-oxo-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylic acid 
• 1355361-76-0 2-acetyl-8-(cyclohexyloxy)-1-oxo-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylic acid 
• 1355361-77-1 8-(cyclohexyloxy)-1-oxo-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylic acid 
• 1355361-91-9 ethyl 8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylate 
• 1355361-85-1 ethyl (2E/Z)-2-[5-(cyclohexyloxy)-1,3-benzothiazol-2-yl]-3-(dimethylamino)acrylate 

Relevant academic research and scientific papers

Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor

RNA dependent RNA polymerases (RdRp) are essential enzymes for flavivirus replication. Starting from an in silico docking analysis we identified a pyridobenzothiazole compound, HeE1-2Tyr, able to inhibit West Nile and Dengue RdRps activity in?vitro, which proved effective against different flaviviruses in cell culture. Crystallographic data show that HeE1-2Tyr binds between the fingers domain and the priming loop of Dengue virus RdRp (Site 1). Conversely, enzyme kinetics, binding studies and mutational analyses suggest that, during the catalytic cycle and assembly of the RdRp-RNA complex, HeE1-2Tyr might be hosted in a distinct binding site (Site 2). RdRp mutational studies, driven by in silico docking analysis, allowed us to locate the inhibition Site 2 in the thumb domain. Taken together, our results provide innovative concepts for optimization of a new class of anti-flavivirus compounds.

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase

Hepatitis C virus (HCV) infection has been recognized as the major cause of liver failure that can lead to hepatocellular carcinoma. Among all the HCV proteins, NS5B polymerase represents a leading target for drug discovery strategies. Herein, we describe