135545-01-6

Basic information

• Product Name: Carbamic acid, [(1S)-1-[(4-fluorophenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester
• CAS NO: 135545-01-6
• Molecular Formula: C16H23FN2O4
• Molecular Weight: 326.368
• Mol File: 135545-01-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-[(4-fluorophenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-[(4-fluorophenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester(135545-01-6)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-[(4-fluorophenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester(135545-01-6)

Safety Data

• Hazardous Substances Data: 135545-01-6(Hazardous Substances Data)

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 41153-30-4 Boc-Phe(p-F) 
• 543-27-1 isobutyl chloroformate 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 135544-90-0 (S)-tert-butyl (1-(4-fluorophenyl)-3-oxopropan-2-yl)carbamate 
• 149267-74-3 (S)-tert-butyl (1-(4-fluorophenyl)-3-hydroxypropan-2-yl)carbamate 
• 135544-92-2 (5S,3E)-5-t-butoxycarbonylamino-6-(4-fluorophenyl)-1-trimethylsilylhex-3-en-1-yne 
• 135545-02-7 (5S,3Z)-5-t-butoxycarbonylamino-6-(4-fluorophenyl)-1-trimethylhex-3-en-1-yne 
• 135544-94-4 (5S,3E)-5-t-butoxycarbonylamino-6-(4-fluorophenyl)hex-3-enoic acid 
• 949897-56-7 (S)-2-Amino-N-[(S)-2-ethylcarbamoyl-1-(4-fluoro-benzyl)-2-hydroxy-ethyl]-3-methyl-butyramide 
• 949897-97-6 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-2-ethylcarbamoyl-1-(4-fluoro-benzyl)-2-hydroxy-ethylcarbamoyl]-2-methyl-propyl}-amide 

Relevant articles and documents

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy

Dipeptide-derived α-keto-amide compounds with potent calpain inhibitory activity have been identified. These reversible covalent inhibitors have IC50 values down to 25 nM and exhibit greatly improved activity in muscle cells compared to the reference compound MDL28170. Several novel calpain inhibitors have shown positive effects on histological parameters in an animal model of Duchenne muscular dystrophy demonstrating their potential as a treatment option for this fatal disease.

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF BRADYKININ ANALOGUES WITH Ψ(E,CH=CH) AND Ψ(CH2-NH) ISOSTERIC PEPTIDE BOND REPLACEMENTS

The synthesis of bradykinin analogues is described in which the Gly4-Phe5, Phe5-Ser6 or the Pro7-Phe8 peptide bond has been replaced by a trans carbon-carbon double bond or by a "reduced" peptide bond.Some of the analogues display high potency and prolonged activity in the rat blood pressure test, indicating increased metabolic stability.A clear selectivity is obtained towards the myotropic effect in the guinea pig ileum.