1355484-68-2

Upstream product

• 17131-19-0 3-(3-methoxy-phenyl)-propane-1,2-diol 
• 24743-14-4 1-allyl-3-methoxybenzene 
• 1355484-31-9 4-(2-bromo-5-methoxy-benzyl)-2,2-dimethyl-[1,3]dioxolane 

Downstream Products

• 1355484-33-1 4-(2-bromo-5-hydroxy-benzyl)-[1,3]dioxolan-2-one 
• 1355484-35-3 4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one 

Relevant academic research and scientific papers

METHOD OF PRODUCING BIPHENOLIC COMPOUND, NOVEL BIPHENYL COMPOUND AND SYNTHESIS METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING PARKINSON'S DISEASE

A method of producing honokiol and analogues thereof, and novel intermediates prepared by virtue thereof are disclosed herein. A pharmaceutical composition for treating Parkinson's disease, which contains honokiol and/or the analogues thereof, is also disclosed herein.

An expedient synthesis of honokiol and its analogues as potential neuropreventive agents

An efficient synthesis of honokiol with Suzuki-Miyaura cross coupling obtained an overall yield of 45%. The proposed approach successfully synthesized several structurally similar alkyl, alkenyl and alkynyl analogues, seven of which showed potential neuropreventive activity against MPP+-induced and CHP/TBHP oxidative stress induced neuroblastoma cell death.