17131-19-0

Upstream product

• 24743-14-4 1-allyl-3-methoxybenzene 
• 10365-98-7 3-methoxyphenylboronic acid 

Downstream Products

• 1355484-32-0 4-(2-bromo-5-methoxy-benzyl)-[1,3]dioxolan-2-one 
• 1355484-33-1 4-(2-bromo-5-hydroxy-benzyl)-[1,3]dioxolan-2-one 
• 1355484-35-3 4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one 
• 1355484-68-2 C₁₀H₁₃BrO₃ 

Relevant academic research and scientific papers

Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group

The palladium-catalyzed meta-olefination of arene-tethered diols attached to a well-designed pyrimidine moiety is presented. Applications of the protocol are illustrated by the synthesis of various diol-based natural products, such as coumarins, phenylpropanoids, stilbenes, and chalcones. Advantages of this method are demonstrated through the easy removal of the template and a gram-scale olefination reaction. Finally, experimental verification, including 1H NMR, ESI-MS and IR, and DFT studies are undertaken to elucidate the mechanistic complexity.

METHOD OF PRODUCING BIPHENOLIC COMPOUND, NOVEL BIPHENYL COMPOUND AND SYNTHESIS METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR TREATING PARKINSON'S DISEASE

A method of producing honokiol and analogues thereof, and novel intermediates prepared by virtue thereof are disclosed herein. A pharmaceutical composition for treating Parkinson's disease, which contains honokiol and/or the analogues thereof, is also disclosed herein.

An expedient synthesis of honokiol and its analogues as potential neuropreventive agents

An efficient synthesis of honokiol with Suzuki-Miyaura cross coupling obtained an overall yield of 45%. The proposed approach successfully synthesized several structurally similar alkyl, alkenyl and alkynyl analogues, seven of which showed potential neuropreventive activity against MPP+-induced and CHP/TBHP oxidative stress induced neuroblastoma cell death.