1355729-65-5Relevant academic research and scientific papers
Difluoroacetic Acid as a New Reagent for Direct C?H Difluoromethylation of Heteroaromatic Compounds
Tung, Truong Thanh,Christensen, S?ren Br?gger,Nielsen, John
, p. 18125 - 18128 (2017)
A technically simple procedure for direct C?H difluoromethylation of heteroaromatic compounds using off-the-shelf difluoroacetic acid as the difluoromethylating reagent has been developed. Mono-difluoromethylation versus bis-difluoromethylation is controlled as the result of the reaction temperature. The reactions described here enable access to the late-stage C?H mono- and bis-difluoromethylation for preparation of tool compounds for chemical biology and provide access to this hitherto untapped substituent for drug discovery.
CATALYST-FREE AND REDOX-NEUTRAL INNATE TRIFLUOROMETHYLATION AND ALKYLATION OF (HETERO)AROMATICS ENABLED BY LIGHT
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Page/Page column 13; 22, (2019/04/26)
The present disclosure relates to reagents and method for performing trifluoromethylation, difluoromethylation or alkylation of aromatic or heteroaromatic rings in a redox-neutral manner without any catalyst which are enabled by light. In addition, there are methods for synthesizing the starting reagents used in the trifluoromethylation, difluoromethylation or alkylation reactions.
