135574-27-5

Upstream product

• 135574-28-6 [(4S,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-2-oxo-oxazolidin-3-yl]-acetaldehyde 
• 135574-25-3 (4S,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-3-(2,2-dimethoxy-ethyl)-oxazolidin-2-one 
• 133343-21-2 (2R,3R)-2,3-Bis-(3-benzyloxy-4-methoxy-phenyl)-oxirane 
• 133343-22-3 (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2-oxide 
• 133343-26-7 (4R,5R)-4,5-Bis-(3-benzyloxy-4-methoxy-phenyl)-[1,3,2]dioxathiolane 2,2-dioxide 
• 135574-23-1 (1R,2S)-1,2-Bis-(3-benzyloxy-4-methoxy-phenyl)-2-(2,2-dimethoxy-ethylamino)-ethanol 

Relevant academic research and scientific papers

Short-cut in the pomeranz-fritsch synthesis of 1-benzyl-isoquinolines; short and efficient syntheses of norrecticuline derivatives and of papaverine

A new methodology for the Pomeranz-Fritsch synthesis of 1-benzyl-1,2-dihydroisoquinolines avoiding pavine or isopavine troubles, has been developed. These intermediates could be reduced to their 1,2,3,4-tetrahydro congeners or aromatized to give isoquinolines, as it was demonstrated by the synthesis of some norrecticuline derivatives 4-7 and of papaverin 8.